Activated c-raf gene in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
Activated c-raf gene in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
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2-氨基-3-甲基咪唑并[4,5-f]喹啉诱导的大鼠肝细胞癌中激活的c-raf基因。
DOI：
10.1016/0006-291x(85)91005-8
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发表时间：
1985
影响因子：
3.1
通讯作者：
T. Sugimura
中科院分区：
文献类型：
--
作者：
F. Ishikawa;F. Takaku;M. Ochiai;K. Hayashi;S. Hirohashi;M. Terada;S. Takayama;M. Nagao;T. Sugimura
由2-氨基-3-甲基咪唑[4,5-f]喹啉(IQ)诱导的大鼠肝细胞癌IQ7在DNA介导的基因转移上产生两个NIH 3T3细胞转化体。进一步检查这些转化体之一并获得二级和三级转化体。二次转化体在裸鼠中具有致瘤性。通过 Southern 印迹分析，该初级转化体中激活的癌基因被鉴定为大鼠 c-raf。
A rat hepatocellular carcinoma, IQ7, induced by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) gave two transformants of NIH 3T3 cells on DNA mediated gene transfer. One of these transformants was examined further and secondary and tertiary transformants were obtained. The secondary transformant was tumorigenic in nude mice. The activated oncogene in this primary transformant was identified as rat c-rafby Southern blot analysis.
激活的原癌基因：对于癌症来说是充分的还是必需的？
DOI：
10.1126/science.3992240
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Duesberg,PH
通讯作者：
Duesberg,PH