Novelty Seeking but not BAS is associated with high dopamine as indicated by a neurotransmitter challenge test using mazindol as a challenge substance
Novelty Seeking but not BAS is associated with high dopamine as indicated by a neurotransmitter challenge test using mazindol as a challenge substance
复制标题
使用马吲哚作为挑战物质的神经递质激发试验表明，寻求新奇而非 BAS 与高多巴胺相关
DOI：
10.1016/j.paid.2004.09.025
复制
发表时间：
2005
影响因子：
4.3
通讯作者：
P. Netter
中科院分区：
文献类型：
--
作者：
Maik C. Stuettgen;J. Hennig;M. Reuter;P. Netter
多巴胺能系统与正常和病理行为的许多方面有关。主要的人格理论假设多巴胺能活动的变化是诸如寻求新奇或外向等特征的基础。在Gray(1973)的人格理论中，行为方法系统(BAS)也与多巴胺能活动联系在一起，并在概念上与冲动、外向和寻求新奇密切相关。这项研究的目的是通过使用BIS/BAS-和新颖性寻求量表来检验BAS与多巴胺相关的生物学基础。采用神经内分泌挑战范式，在平衡、随机、安慰剂对照的交叉设计中，对50名参与者应用选择性多巴胺再摄取抑制剂Mazindol。比较两组BAS评分高低者的催乳素(PRL)反应。未发现对BAS量表的任何一个有显著影响。相比之下，与NS−相比，高新颖性寻求(NS+)的特征是催乳素水平总体较低，并且与NS−相比，Mazindol对PRL的反应迟钝。这些结果表明，NS与高水平的多巴胺有关，根据NS，马吲哚作为一种激发物质有助于研究多巴胺能反应性。此外，他们还指出，BAS与多巴胺能神经递质系统的关系不那么明显。讨论了可能的原因。
The dopaminergic system is linked to many aspects of normal and pathological behavior. Major theories of personality hypothesize variation in dopaminergic activity to underlie traits such as novelty seeking or extraversion. In Gray’s (1973) theory of personality the behavioral approach system (BAS) is also linked to dopaminergic activity and conceptually closely related to impulsivity, extraversion, and novelty seeking. The aim of this study is to examine the biological basis of the BAS with respect to dopamine by use of the BIS/BAS- and Novelty Seeking scales. Using a neuroendocrine challenge paradigm, mazindol, a selective dopamine reuptake inhibitor, was applied to 50 participants in a balanced randomized placebo-controlled crossover design. Prolactin (PRL) responses were compared for two groups of high and low BAS scorers. No significant effects could be found for any of the BAS scales. In contrast, high Novelty Seeking (NS+) was characterized by an overall lower level of prolactin as compared to NS− and showed a blunted PRL response to mazindol as compared to NS−. These results indicate that NS is associated with high levels of dopamine, and that mazindol as a challenge substance is useful to investigate dopaminergic responsivity according to NS. Moreover, they indicate that BAS less clearly relates to the dopaminergic neurotransmitter system. Possible reasons are discussed.
大脑的结节漏斗多巴胺能神经元：激素调节。
影响因子：
--
作者：
Porter,JC;Kedzierski,W;Aguila-Mansilla,N;Jorquera,BA;González,HA
通讯作者：
González,HA
多巴胺和人格结构：激动剂诱导的多巴胺活动与积极情绪的关系。
影响因子：
7.6
作者：
Depue,RA;Luciana,M;Arbisi,P;Collins,P;Leon,A
通讯作者：
Leon,A