Neonatal Exposure to Leptin Augments Diet‐induced Obesity in Leptin‐deficient Ob/Ob Mice
Neonatal Exposure to Leptin Augments Diet‐induced Obesity in Leptin‐deficient Ob/Ob Mice
复制标题
新生儿接触瘦素会增加瘦素缺乏的 Ob/Ob 小鼠饮食引起的肥胖
作者：
S. Yura;H. Itoh;N. Sagawa;Hiroshi Yamamoto;H. Masuzaki;K. Nakao;Makoto Kawamura;Haruta Mogami;Y. Ogawa;S. Fujii
目的：流行病学证据表明，子宫内营养不良与成年后的肥胖和相关有害代谢后遗症密切相关。最近，使用野生型（wt）小鼠模型，其中后代暴露于宫内营养不良（UN后代），我们报告说，新生儿生长期间过早的瘦素激增促进了下丘脑能量调节回路的终身变化，因此在成年期高脂饮食（HFD）的明显肥胖症的发展中发挥了重要作用。在这里，我们使用瘦素缺陷型ob/ob小鼠进一步评估瘦素在肥胖发育起源中的重要参与。
Objective: Epidemiological evidence has revealed that undernutrition in utero is closely associated with obesity and related detrimental metabolic sequelae in adulthood. Recently, using a wild‐type (wt) mouse model in which offspring were exposed to intrauterine undernutrition (UN offspring), we reported that the premature leptin surge during neonatal growth promotes lifelong changes in energy regulating circuitry in the hypothalamus, thus playing an important role in the development of pronounced obesity on a high‐fat diet (HFD) in adulthood. Here, we further evaluate the essential involvement of leptin in the developmental origins of obesity using leptin‐deficient ob/ob mice.
影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
影响因子：
15.9
作者：
Ahima, RS;Prabakaran, D;Flier, JS
通讯作者：
Flier, JS
影响因子：
56.9
作者：
Boston, BA;Blaydon, KM;Cone, RD
通讯作者：
Cone, RD