Oligodendroglia heterogeneity in the human central nervous system.
Oligodendroglia heterogeneity in the human central nervous system.
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DOI：
10.1007/s00401-021-02390-4
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发表时间：
2022-03
影响因子：
12.7
通讯作者：
Williams A
中科院分区：
文献类型：
--
作者：
Seeker LA;Williams A
这是发现少突胶质细胞的一百周年，我们越来越意识到它们在大脑发育、成人学习、正常衰老和整个生命过程中的疾病中的重要性，甚至在那些经典上被认为是神经元的疾病中。这引起了对少突胶质细胞的更多兴趣，因为它们作为中枢神经系统中的可再生细胞更易于处理，因此可用于许多神经退行性/神经发育疾病的潜在治疗。然而，少突胶质细胞并不完全相同。即使从第一次描述开始，也描述了细胞之间的形态差异。随着描述人类组织中这些差异的先进技术，正在发现少突胶质细胞的复杂性，这表明明显的功能差异可能在确定脆弱性和对疾病的反应以及潜在治疗方法的靶向方面至关重要。现在是时候回顾我们在发现和理解健康和神经病理学中少突胶质细胞异质性方面所取得的进展。
It is the centenary of the discovery of oligodendrocytes and we are increasingly aware of their importance in the functioning of the brain in development, adult learning, normal ageing and in disease across the life course, even in those diseases classically thought of as neuronal. This has sparked more interest in oligodendroglia for potential therapeutics for many neurodegenerative/neurodevelopmental diseases due to their more tractable nature as a renewable cell in the central nervous system. However, oligodendroglia are not all the same. Even from the first description, differences in morphology were described between the cells. With advancing techniques to describe these differences in human tissue, the complexity of oligodendroglia is being discovered, indicating apparent functional differences which may be of critical importance in determining vulnerability and response to disease, and targeting of potential therapeutics. It is timely to review the progress we have made in discovering and understanding oligodendroglial heterogeneity in health and neuropathology.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
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通讯作者：
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DOI：
10.3390/life11020125
发表时间：
2021-02-06
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
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通讯作者：
Williams A
影响因子：
11.2
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通讯作者：
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DOI：
10.1073/pnas.1507125112
发表时间：
2015-06-09
影响因子：
11.1
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通讯作者：
Quake SR
DOI：
10.1016/j.cub.2015.07.056
发表时间：
2015-09-21
期刊：
Current biology : CB
影响因子：
--
作者：
Bechler ME;Byrne L;Ffrench-Constant C
通讯作者：
Ffrench-Constant C