Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis.
Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis.
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DOI：
10.1002/ana.24620
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发表时间：
2016-05
影响因子：
11.2
通讯作者：
Stankoff, Bruno
中科院分区：
文献类型：
--
作者：
Bodini, Benedetta;Veronese, Mattia;Garcia-Lorenzo, Daniel;Battaglini, Marco;Poirion, Emilie;Chardain, Audrey;Freeman, Leorah;Louapre, Celine;Tchikviladze, Maya;Papeix, Caroline;Dolle, Frederic;Zalc, Bernard;Lubetzki, Catherine;Bottlaender, Michel;Turkheimer, Federico;Stankoff, Bruno
多发性硬化（MS）患者髓鞘丢失和修复的定量体内成像对于了解疾病的发病机制和评估早髓鞘形成治疗至关重要。匹兹堡化合物B（[11 C]PiB）选择性结合中枢神经系统白色物质中的髓鞘，可用作正电子发射断层扫描（PET）示踪剂，以探索MS中的髓鞘动力学。将患有活动性复发缓解型MS的患者（n = 20）和健康对照（n = 8）纳入一项纵向试验，该试验将PET与[11 C]PiB和磁共振成像相结合。导出了反映髓鞘含量的[11 C]PiB分布体积比的体素图。三个动态指数计算每个病人：髓鞘含量变化的全球指数，脱髓鞘指数和髓鞘再生指数。基线时，从外观正常的白色物质到MS病变，[11 C]PiB结合逐渐减少，反映了髓鞘含量的下降。白色病变的特征是在体素水平上示踪剂结合的向心减少。在随访期间，发现所有髓鞘含量变化指标的患者间变异性较高。动态髓鞘再生与临床残疾呈负相关（扩展残疾状态量表p = 0.006，β系数= -0.67; MS严重程度量表p = 0.003，β系数= -0.68），而脱髓鞘指数无显著临床相关性。[11 C]PiB PET可以量化MS中的髓鞘动力学，并根据患者的个体髓鞘再生潜力对患者进行分层，这与临床残疾显著相关。这种技术应被认为是评估新的早髓鞘药物。神经病学年鉴2016;79：726-738
Quantitative in vivo imaging of myelin loss and repair in patients with multiple sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate promyelinating therapies. Selectively binding myelin in the central nervous system white matter, Pittsburgh compound B ([11C]PiB) can be used as a positron emission tomography (PET) tracer to explore myelin dynamics in MS. Patients with active relapsing‐remitting MS (n = 20) and healthy controls (n = 8) were included in a longitudinal trial combining PET with [11C]PiB and magnetic resonance imaging. Voxel‐wise maps of [11C]PiB distribution volume ratio, reflecting myelin content, were derived. Three dynamic indices were calculated for each patient: the global index of myelin content change; the index of demyelination; and the index of remyelination. At baseline, there was a progressive reduction in [11C]PiB binding from the normal‐appearing white matter to MS lesions, reflecting a decline in myelin content. White matter lesions were characterized by a centripetal decrease in the tracer binding at the voxel level. During follow‐up, high between‐patient variability was found for all indices of myelin content change. Dynamic remyelination was inversely correlated with clinical disability (p = 0.006 and beta‐coefficient = –0.67 with the Expanded Disability Status Scale; p = 0.003 and beta‐coefficient = –0.68 with the MS Severity Scale), whereas no significant clinical correlation was found for the demyelination index. [11C]PiB PET allows quantification of myelin dynamics in MS and enables stratification of patients depending on their individual remyelination potential, which significantly correlates with clinical disability. This technique should be considered to assess novel promyelinating drugs. Ann Neurol 2016;79:726–738
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DOI：
10.1007/s00259-013-2682-6
发表时间：
2014-05-01
影响因子：
9.1
作者：
Faria, Daniele de Paula;Copray, Sjef;de Vries, Erik F. J.
通讯作者：
de Vries, Erik F. J.
影响因子：
158.5
作者：
Chang, A;Tourtellotte, WW;Trapp, BD
通讯作者：
Trapp, BD
影响因子：
11.2
作者：
Moll, Natalia M.;Rietsch, Anna M.;Thomas, Smitha;Ransohoff, Amy J.;Lee, Jar-Chi;Fox, Robert;Chang, Ansi;Ransohoff, Richard M.;Fisher, Elizabeth
通讯作者：
Fisher, Elizabeth
影响因子：
5
作者：
Patani, R.;Balaratnam, M.;Reynolds, R.
通讯作者：
Reynolds, R.
影响因子：
14.5
作者：
Howell, Owain W.;Reeves, Cheryl A.;Reynolds, Richard
通讯作者：
Reynolds, Richard