Acute-Phase Serum Amyloid A May Predict Microvascular Invasion and Early Tumor Recurrence in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma Undergoing Liver Resection
Acute-Phase Serum Amyloid A May Predict Microvascular Invasion and Early Tumor Recurrence in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma Undergoing Liver Resection
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急性期血清淀粉样蛋白 A 可以预测接受肝切除术的乙型肝炎病毒相关肝细胞癌患者的微血管侵袭和早期肿瘤复发
DOI：
10.1080/08941939.2022.2035858
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发表时间：
2022-02
影响因子：
1.9
通讯作者：
Liu F
中科院分区：
文献类型：
--
作者：
Guo X;Zhang W;Du J;Tao R;Dong W;Huang J;Zhang J;Pan Z;Zhou W;Zhu X;Liu H;Liu F
目的探讨急性时相蛋白血清淀粉样蛋白A（aSAA）对B肝炎病毒（HBV）相关性肝细胞癌（HCC）微血管浸润（MVI）和早期复发的影响。采用免疫组化法检测172例肝癌组织中aSAA的表达，并进一步采用Western blotting法检测20例肝癌组织及其相应的门静脉癌栓（PVTT）中aSAA的表达。进行考克斯和logit回归分析。探索性亚组分析被用来平衡潜在的confounders. ResultsHBV相关的HCC患者高aSAA水平往往有高HBV-DNA载量。Logit和考克斯回归分析显示aSAA高表达不仅是MVI的独立危险因素，（OR 5.384，95%CI 2.286- 13.301，P < 0.001），而且对早期复发也有影响（HR 6.040，95%CI 1.970- 18.540，P = 0.002）、总复发率（HR 3.720，95%CI 2.140- 6.450，P < 0.001）和总生存率（HR 4.15，95%CI 2.380- 7.230，P < 0.001）。亚组分析表明，aSAA的效果在所有检查的亚组中一致。PVTT组织中aSAA蛋白水平明显高于相应肿瘤组织。高HBV-DNA水平和大肿瘤大小是高水平aSAA患者早期肝癌复发的独立危险因素。结论aSAA高表达是HBV相关肝癌患者肝切除术后MVI和早期肿瘤复发的独立危险因素。因此，aSAA蛋白水平可能是预测这些患者中MVI和早期复发的有希望的生物标志物。
ObjectiveTo elucidate the impact of acute-phase protein serum amyloid A (aSAA) on microvascular invasion (MVI) and early recurrence in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).MethodsHBV-related HCC patients (n= 192) undergoing liver resection were included in the study. The protein levels of aSAA were analyzed by immunohistochemical staining in 172 tumor specimens, and further detected via western blotting in HCC and their corresponding portal vein tumor thrombus (PVTT) (n= 20). Cox and logit regression analysis was performed. Exploratory subgroup analysis was used to balance the potential confounders.ResultsHBV-related HCC patients with high aSAA levels tended to have high HBV-DNA loads. Logit and Cox regression analyses revealed high expression of aSAA is an independent risk factor not only for MVI (OR 5.384, 95% CI 2.286–13.301,P< 0.001) but also for early recurrence (HR 6.040, 95% CI 1.970–18.540,P= 0.002), overall recurrence (HR 3.720, 95% CI 2.140–6.450,P< 0.001), and overall survival (HR 4.15, 95% CI 2.380–7.230,P< 0.001). Subgroup analysis showed that the effects of aSAA were consistent across all subgroups examined. Additionally, the aSAA protein level was significantly higher in PVTT than that in its corresponding tumor specimen. A high HBV-DNA level and large tumor size were the independent risk factors for early HCC recurrence in patients with high levels of aSAA.ConclusionsHigh expression of aSAA was an independent risk factor for MVI and early tumor recurrence in HBV-related HCC patients after liver resection. The aSAA protein level could thus be a promising biomarker for predicting MVI and early recurrence in these patients.
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子宫宫颈癌中血清淀粉样蛋白A的表达。
影响因子：
2.6
作者：
Ren Y;Wang H;Lu D;Xie X;Chen X;Peng J;Hu Q;Shi G;Liu S
通讯作者：
Liu S
血清淀粉样蛋白 A 是肝细胞癌的一种新型预后生物标志物。
DOI：
10.7314/apjcp.2014.15.24.10713
发表时间：
2015-01
期刊：
Asian Pac J Cancer Prev
影响因子：
--
作者：
Wang, Jia-Xing;Zhou, Jian;Fan, Jia;Qiu, Shuang-Jian
通讯作者：
Qiu, Shuang-Jian
影响因子：
8
作者：
Hansen, M. T.;Forst, B.;Grigorian, M.
通讯作者：
Grigorian, M.
影响因子：
29.4
作者：
Roayaie S;Blume IN;Thung SN;Guido M;Fiel MI;Hiotis S;Labow DM;Llovet JM;Schwartz ME
通讯作者：
Schwartz ME
影响因子：
5.1
作者：
Marrero, Jorge A;Pelletier, Shawn
通讯作者：
Pelletier, Shawn