Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.
Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.
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DOI：
10.1038/s41390-021-01753-7
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发表时间：
2022-08
影响因子：
3.6
通讯作者：
Sylvester, Karl G.
中科院分区：
文献类型：
--
作者：
Reiss, Jonathan D.;Chang, Alan L.;Mayo, Jonathan A.;Bianco, Katherine;Lee, Henry C.;Stevenson, David K.;Shaw, Gary M.;Aghaeepour, Nima;Sylvester, Karl G.
妊娠期高血压疾病和母体糖尿病严重影响胎儿和新生儿的生长，但中间代谢紊乱和胎儿生长改变的相关介质仍不清楚。我们试图确定是否有不同的新生儿筛选代谢模式的影响，产妇高血压疾病或糖尿病在子宫内的新生儿。一项回顾性观察性研究，结合2005年至2010年期间加州州出生和住院记录的相关数据，研究不同的新生儿筛查代谢物。共纳入41，333对母婴。糖尿病母亲的婴儿表现出与短链酰基肉毒碱和游离肉毒碱的关联。患有重度子痫前期和慢性高血压叠加子痫前期的母亲所生的婴儿乙酰肉碱、游离肉碱和鸟氨酸水平发生改变。这些结果进一步强调了胎龄指定的大小。糖尿病母亲的婴儿表现出不完全β氧化和脂质代谢改变的代谢体征。患有妊娠期高血压疾病的母亲的婴儿携带分析物信号，其可能通过改变的一氧化氮信号传导反映氧化应激。新生儿筛查分析物组成受这些母体状况的影响，并进一步与出生时的新生儿尺寸指定相关。
Hypertensive disorders of pregnancy and maternal diabetes profoundly affect fetal and newborn growth, yet disturbances in intermediate metabolism and relevant mediators of fetal growth alterations remain poorly defined. We sought to determine whether there are distinct newborn screen metabolic patterns among newborns affected by maternal hypertensive disorders or diabetes in utero. A retrospective observational study investigating distinct newborn screen metabolites in conjunction with data linked to birth and hospitalization records in the state of California between 2005 and 2010. A total of 41,333 maternal–infant dyads were included. Infants of diabetic mothers demonstrated associations with short-chain acylcarnitines and free carnitine. Infants born to mothers with preeclampsia with severe features and chronic hypertension with superimposed preeclampsia had alterations in acetylcarnitine, free carnitine, and ornithine levels. These results were further accentuated by size for gestational age designations. Infants of diabetic mothers demonstrate metabolic signs of incomplete beta oxidation and altered lipid metabolism. Infants of mothers with hypertensive disorders of pregnancy carry analyte signals that may reflect oxidative stress via altered nitric oxide signaling. The newborn screen analyte composition is influenced by the presence of these maternal conditions and is further associated with the newborn size designation at birth.
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影响因子：
2.4
作者：
Fenton TR;Kim JH
通讯作者：
Kim JH
影响因子：
8
作者：
Boghossian, Nansi S.;Geraci, Marco;Horbar, Jeffrey D.
通讯作者：
Horbar, Jeffrey D.
影响因子：
8.2
作者：
Devaskar, Sherin U.;Thamotharan, Manikkavasagar
通讯作者：
Thamotharan, Manikkavasagar
影响因子：
7.7
作者：
Dabelea, D;Hanson, RL;Knowler, WC
通讯作者：
Knowler, WC
DOI：
10.1016/b978-0-12-407866-6.00009-2
发表时间：
2015-01-01
期刊：
CHESLEY'S HYPERTENSIVE DISORDERS IN PREGNANCY, 4TH EDITION
影响因子：
--
作者：
Davidge, Sandra T.;de Groot, Christianne J. M.;Taylor, Robert N.
通讯作者：
Taylor, Robert N.