Biomarkers of Toxic Exposure and Oxidative Stress Among U.S. Adult Users of Premium Cigar Versus Other Cigar Subtypes: 2013-2019.
Biomarkers of Toxic Exposure and Oxidative Stress Among U.S. Adult Users of Premium Cigar Versus Other Cigar Subtypes: 2013-2019.
复制标题
DOI：
10.1093/ntr/ntad054
复制
发表时间：
2023-07-28
影响因子：
4.7
通讯作者：
Khan, Ali S.
中科院分区：
文献类型：
--
作者：
Dai, Hongying Daisy;Benowitz, Neal L.;Rogan, Eleanor;Degarege, Abraham;Buckley, James;Khan, Ali S.
雪茄目前是美国成年人中使用量第二高的可燃烟草产品，但有关优质雪茄与其他雪茄亚型使用对健康影响的知识有限。该研究分析了2013-2019年期间收集的烟草与健康研究人群评估第1-5波的生物标本数据（n=31 875）。 进行了多变量广义估计方程，考虑人内聚类，以检查五类有害和潜在有害成分沿着氧化应激生物标志物的尿液暴露生物标志物（BOE）的差异（尿8-异前列烷）在高级雪茄的独家用户与其他独家雪茄亚型之间的差异（即非优质大雪茄、小雪茄和过滤雪茄）、香烟和非烟草使用者。与非烟草使用者相比，独家高级雪茄使用者的尼古丁代谢物可替宁（5.8 vs. 0.5 ng/mg，p <.0001）、烟草特异性亚硝胺（TSNA）（4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁醇（NNAL）：7.8 vs. 1.3 pg/mg，p <.0001）和挥发性有机化合物（VOC）（N-乙酰基-S-（2-氰乙基）-L-半胱氨酸（CYMA，丙烯腈）：4.7 vs. 1.6 ng/mg，p <.0001）的几何平均浓度更高。 与其他烟草使用者群体相比，独家优质雪茄使用者不太可能是日常使用者，并且与独家非优质大雪茄使用者具有可比的BOE，但通常低于独家小雪茄，过滤雪茄和卷烟吸烟者。每日独家高级雪茄使用者的尼古丁和TSNA暴露量相似，但多环芳烃和挥发性有机化合物的暴露量低于独家小雪茄和过滤雪茄使用者。高级雪茄的使用表现出与其他雪茄亚型使用者不同的有毒物质暴露。对优质雪茄的监管需要正式确定产品定义，并考虑到对人群健康的影响。这项人口研究提供了关于BOE的重要信息，以及使用优质雪茄的潜在危害及其潜在的健康影响。目前，由于使用频率较低，优质雪茄对整体人群健康的风险似乎相对较低。然而，未来对其他烟草产品的监管可能会改变优质雪茄使用的格局，并改变整体健康影响。
Cigars are currently the second-highest-used combustible tobacco product among U.S. adults, but knowledge about health effects of premium cigars versus other cigar subtype use is limited. This study analyzed the biospecimen data (n = 31 875) from Waves 1-5 of the Population Assessment of Tobacco and Health Study, collected during 2013–2019. Multivariable generalized estimation equations, accounting for within-person clustering, were conducted to examine differences in urine biomarkers of exposure (BOE) from five classes of harmful and potentially harmful constituents along with a biomarker of oxidative stress (urine 8-isoprostane) among exclusive users of premium cigars versus other exclusive cigar subtypes (ie, non-premium large cigars, cigarillos, and filtered cigars), cigarettes, and non-tobacco users. In comparison to non-tobacco users, exclusive premium cigar users had higher geometric mean concentrations of the nicotine metabolite cotinine (5.8 vs. 0.5ng/mg, p < .0001), tobacco-specific nitrosamine (TSNA) (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL): 7.8 vs. 1.3pg/mg, p < .0001), and volatile organic compound (VOC) (N-Acetyl-S-(2-cyanoethyl)-L-cysteine (CYMA, acrylonitrile): 4.7 vs. 1.6ng/mg, p < .0001). Exclusive premium cigar users were less likely to be daily users than other tobacco user groups and had comparable BOEs with exclusive non-premium large cigar users but generally lower BOEs than exclusive cigarillo, filtered cigar, and cigarette smokers. Daily exclusive premium cigar users had similar nicotine and TSNA exposure but lower exposure to polycyclic aromatic hydrocarbons and volatile organic compounds than exclusive cigarillo and filtered cigar users. Premium cigar use exhibits different exposure to toxicants from other cigar subtype users. Regulations of premium cigars need to formalize product definition and take the population’s health effects into consideration. This population study provides important information on BOE and potential harm with premium cigar use and its potential health effects. At present, premium cigars appear to pose a relatively low overall population health risk due to low frequency of use. However, future regulation of other tobacco products might change the landscape of premium cigar use and alter the overall health impact.
登录
查看更多内容
DOI：
10.1158/1055-9965.epi-16-0675
发表时间：
2017-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Chang CM;Edwards SH;Arab A;Del Valle-Pinero AY;Yang L;Hatsukami DK
通讯作者：
Hatsukami DK
影响因子：
--
作者：
Lawler, Tameka S;Stanfill, Stephen B;Watson, Clifford H
通讯作者：
Watson, Clifford H
DOI：
10.1016/j.mrrev.2021.108365
发表时间：
2021-01
期刊：
Mutation research. Reviews in mutation research
影响因子：
--
作者：
Caliri AW;Tommasi S;Besaratinia A
通讯作者：
Besaratinia A
影响因子：
13.8
作者：
Goniewicz, Maciej L.;Smith, Danielle M.;Hyland, Andrew J.
通讯作者：
Hyland, Andrew J.
影响因子：
3.8
作者：
Chang, Cindy M.;Rostron, Brian L.;van Bemmel, Dana M.
通讯作者：
van Bemmel, Dana M.