Disrupted modular organization of primary sensory brain areas in schizophrenia.
Disrupted modular organization of primary sensory brain areas in schizophrenia.
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DOI：
10.1016/j.nicl.2018.02.035
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Bifone A
中科院分区：
文献类型：
--
作者：
Bordier C;Nicolini C;Forcellini G;Bifone A
使用功能性MRI和其他神经影像学技术，在精神分裂症（SCZ）患者中一直观察到异常的大脑静息状态功能连接。图论方法提供了一个框架来研究这些有缺陷的功能相互作用及其对大脑连接网络组织的影响。一些研究表明，SCZ患者的功能模块内和功能模块之间的连接分布发生了变化，这表明功能分离和整合不平衡。然而，没有重大的改变模块化组织已报告在患者中，明确识别受影响的神经基板仍然难以捉摸。最近，它已被证明，目前的模块化分析方法遭受一个基本的和严重的分辨率限制，因为它们无法检测到的功能，是小于由整个连接网络的大小所确定的规模。该分辨率限值可能妨碍了在先前研究中分辨患者和对照之间差异的能力。在这里，我们应用Surprise，一种新的分辨率无限制的方法，来研究一个大的SCZ患者队列和匹配的健康对照组中静息状态功能连接网络的模块化组织。利用这些重要的方法学进展，我们发现了新的证据，涉及SCZ患者的初级感觉，听觉和视觉领域的大量碎片和重组。相反，通常与高级认知功能相关的额叶和前额叶区域似乎基本上不受影响，变化选择性地涉及语言和语音处理区域。我们的研究结果支持这一假设，认知功能障碍SCZ可能涉及赤字已经发生在早期阶段的感觉处理。
Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ) using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organization of brain connectivity networks. A few studies have shown altered distribution of connectivity within and between functional modules in SCZ patients, an indication of imbalanced functional segregation ad integration. However, no major alterations of modular organization have been reported in patients, and unambiguous identification of the neural substrates affected remains elusive. Recently, it has been demonstrated that current modularity analysis methods suffer from a fundamental and severe resolution limit, as they fail to detect features that are smaller than a scale determined by the size of the entire connectivity network. This resolution limit is likely to have hampered the ability to resolve differences between patients and controls in previous studies. Here, we apply Surprise, a novel resolution limit-free approach, to study the modular organization of resting state functional connectivity networks in a large cohort of SCZ patients and in matched healthy controls. Leveraging these important methodological advances we find new evidence of substantial fragmentation and reorganization involving primary sensory, auditory and visual areas in SCZ patients. Conversely, frontal and prefrontal areas, typically associated with higher cognitive functions, appear to be largely unaffected, with changes selectively involving language and speech processing areas. Our findings support the hypothesis that cognitive dysfunction in SCZ may involve deficits occurring already at early stages of sensory processing.
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发表时间：
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期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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