Splenic inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunophenotypic study of 12 cases.
Splenic inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunophenotypic study of 12 cases.
复制标题
脾炎性肌纤维母细胞瘤（炎性假瘤）：12例临床病理和免疫表型研究。
DOI：
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发表时间：
2001
影响因子：
4.6
通讯作者：
S. Abbondanzo
中科院分区：
文献类型：
--
作者：
T. Neuhauser;Gregory A. Derringer;Lester D. R. Thompson;J. Fanburg;N. Aguilera;J. W. Andriko;W. Chu;S. Abbondanzo
上下文
炎性假瘤是一种罕见且神秘的疾病。梭形细胞具有肌成纤维细胞的特征。由于这些病变与炎性纤维肉瘤的关系不明确，其生物学行为也不明确，因此目前将炎性假瘤归类为炎性肌纤维母细胞瘤（IMT）。迄今为止，只有病例报告或小系列已发表的这些肿瘤，这是原发于脾脏。
设计
在这项研究中，我们描述了12例脾脏IMT的临床，形态学和免疫表型的结果，并探讨其与EB病毒（EBV）的关系。
结果
患者包括8名女性和3名男性，年龄范围为19至77岁（平均53岁;中位数60岁）。1例患者的人口统计学数据不可用。患者通常表现为腹痛（n = 5）和发热（n = 4）。相关病变包括肾细胞癌（n = 2）、结肠腺癌（n = 1）和胆囊炎（n = 1）。所有肿瘤均由温和的梭形细胞增殖和可变的混合炎性成分组成。有2种生长模式，即细胞梭形细胞模式和少细胞纤维模式。免疫组化证实了梭形细胞的肌纤维母细胞性质。2例梭形细胞呈EBV潜伏膜蛋白1阳性，10例梭形细胞中6例呈EBV编码RNA阳性。随访8例患者; 6例存活，无复发证据，2例死于其他原因。
结论
脾脏IMT是一种罕见的病变，结合临床、组织学和免疫表型结果可以将其与其他疾病区分开来。Epstein-Barr病毒可能在脾脏IMT的发病机制中发挥作用，脾脏IMT可能与伴随疾病或恶性肿瘤有关。大多数脾脏IMT具有良好的长期预后。
CONTEXT
Inflammatory pseudotumor is an uncommon and enigmatic lesion. The spindle cells found in this tumor have features of myofibroblasts. Because of the indefinite relationship of these lesions with inflammatory fibrosarcoma and their indefinite biologic behavior, inflammatory pseudotumor is currently classified as inflammatory myofibroblastic tumor (IMT). To date, only case reports or small series have been published on these tumors, which are primary in the spleen.
DESIGN
In this study, we describe the clinical, morphologic, and immunophenotypic findings of 12 cases of splenic IMT and examine their relationship to Epstein-Barr virus (EBV).
RESULTS
The patients included 8 women and 3 men, ranging from 19 to 77 years of age (mean, 53 years; median, 60 years). Demographic data were unavailable for 1 patient. Patients generally presented with abdominal pain (n = 5) and fever (n = 4). Associated lesions included renal cell carcinoma (n = 2), colonic adenocarcinoma (n = 1), and cholecystitis (n = 1). All tumors were composed of a bland spindle cell proliferation in association with a variable mixed inflammatory component. There were 2 growth patterns, namely, a cellular spindle cell pattern and a hypocellular fibrous pattern. An immunohistochemical panel confirmed the myofibroblastic nature of the spindle cells. The spindle cells of 2 cases were immunoreactive for EBV latent membrane protein 1, whereas 6 of 10 cases were positive for EBV-encoded RNA using in situ hybridization. Follow-up was available for 8 patients; 6 were alive with no evidence of recurrence and 2 were dead of other causes.
CONCLUSION
Splenic IMTs are uncommon lesions that can be distinguished from other conditions using a combination of clinical, histologic, and immunophenotypic findings. Epstein-Barr virus may play a role in the pathogenesis of splenic IMT, and there may be an association of splenic IMT with concomitant disease or malignancy. Most splenic IMTs have an excellent long-term prognosis.
影响因子：
3.9
作者：
Pal, Nabanita;Kim, Taeyeon;Park, Jae-Seo;Cho, Eun-Bum
通讯作者：
Cho, Eun-Bum
影响因子：
3.3
作者：
ARBER, DA;KAMEL, OW;WEISS, LM
通讯作者：
WEISS, LM