Subjective cognitive complaints and amyloid burden in cognitively normal older individuals.
Subjective cognitive complaints and amyloid burden in cognitively normal older individuals.
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DOI：
10.1016/j.neuropsychologia.2012.08.011
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发表时间：
2012-10
期刊：
影响因子：
2.6
通讯作者：
Rentz DM
中科院分区：
文献类型：
--
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
越来越多的证据表明，主观认知主诉（SCC）可能表明患有临床前阿尔茨海默病（AD）的个体的轻微认知下降特征。在这项研究中，我们试图建立在以前的研究中，通过使用正电子发射断层扫描与认知正常的老年人中的PIB化合物B（PiB-PET）将SCC和淀粉样蛋白-β沉积联系起来。对131名受试者（平均年龄73.5 ± 6岁）进行了三次主观认知问卷调查和简短的神经心理成套测验。主观记忆投诉综合评分和皮质PiB结合之间的关系被发现是显着的，即使在控制抑郁症状。相比之下，有记忆和执行功能和皮质PiB绑定的客观认知措施之间没有显着的关系。我们的研究表明，SCC可能是AD病理学的早期指标，可在显著的客观损害之前检测到。
Accumulating evidence suggests that subjective cognitive complaints (SCC) may indicate subtle cognitive decline characteristic of individuals with preclinical Alzheimer’s disease (AD). In this study, we sought to build upon previous studies by associating SCC and amyloid-β deposition using Positron Emission Tomography with Pittsburg Compound B (PiB-PET) in cognitively normal older individuals. One-hundred thirty one subjects (mean age 73.5 ± 6) were administered three subjective cognitive questionnaires and a brief neuropsychological battery. A relationship between a subjective memory complaints composite score and cortical PiB binding was found to be significant, even after controlling for depressive symptoms. By contrast, there were no significant relationships between objective cognitive measures of memory and executive functions and cortical PiB binding. Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment.
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影响因子：
2.4
作者：
Hohman TJ;Beason-Held LL;Lamar M;Resnick SM
通讯作者：
Resnick SM
影响因子：
5.7
作者：
GAGNON, M;DARTIGUES, JF;BARBERGERGATEAU, P
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BARBERGERGATEAU, P
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作者：
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作者：
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通讯作者：
Blacker, Deborah
DOI：
10.1016/j.jalz.2011.02.007
发表时间：
2011-11
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
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作者：
Tomaszewski Farias S;Mungas D;Harvey DJ;Simmons A;Reed BR;Decarli C
通讯作者：
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