Subjective cognitive complaints and longitudinal changes in memory and brain function.
Subjective cognitive complaints and longitudinal changes in memory and brain function.
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DOI：
10.1037/a0020859
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发表时间：
2011-01
期刊：
影响因子：
2.4
通讯作者：
Resnick SM
中科院分区：
文献类型：
--
作者：
Hohman TJ;Beason-Held LL;Lamar M;Resnick SM
主观认知主诉通常用于诊断记忆和其他认知障碍。这项研究调查了 98 名平均年龄为 75 岁的参与者在记忆表现过程中认知抱怨是否与认知的纵向变化和区域脑功能的横截面差异相关。认知失败问卷 (CFQ) 评估了认知抱怨，并使用混合效应回归模型来确定平均 CFQ 分数是否可以预测 11.5 年期间认知功能的变化率。 CFQ 分数越高，反映出主观抱怨的增加，与加州言语学习测试中即时回忆和延迟回忆的下降幅度越大相关。基于体素的回归分析用于确定在静息状态以及言语和图形记忆任务期间 CFQ 评分与 PET 测量的局部脑血流量之间的横截面关系。较高水平的认知问题与记忆任务期间岛叶、舌和小脑区域的活动增加有关。这些发现为主观认知抱怨作为与年龄相关的记忆和大脑活动变化的标志的有效性提供了一些支持。
Subjective cognitive complaints are often used in the diagnosis of memory and other cognitive impairment. This study examined whether cognitive complaints are associated with longitudinal changes in cognition and cross-sectional differences in regional brain function during memory performance in 98 participants with a mean age of 75. The Cognitive Failures Questionnaire (CFQ) assessed cognitive complaints and mixed effects regression models were used to determine whether mean CFQ scores predicted rates of change in cognitive function over a period of 11.5 years. Higher CFQ scores, reflecting increased subjective complaints, were associated with steeper rates of decline in immediate and delayed recall on the California Verbal Learning Test. Voxel-based regression analysis was used to determine the cross-sectional relationship between CFQ scores and regional cerebral blood flow measured by PET during a resting condition and during verbal and figural memory tasks. Higher levels of cognitive complaints were associated with increased activity in insular, lingual and cerebellar areas during memory tasks. These findings offer some support for the validity of subjective cognitive complaints as markers of age related changes in memory and brain activity.
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影响因子：
3.2
作者：
Grady, CL;Springer, MV;Winocur, G
通讯作者：
Winocur, G
DOI：
10.1073/pnas.2235925100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Lustig, C;Snyder, AZ;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
64.8
作者：
Nyberg, L;McIntosh, AR;Tulving, E
通讯作者：
Tulving, E
影响因子：
3.4
作者：
Mendes, Tiago;Gino, Sandra;de Mendonca, Alexandre
通讯作者：
de Mendonca, Alexandre
影响因子：
4
作者：
RABBITT, P;ABSON, V
通讯作者：
ABSON, V