The influence of hemodynamic stress factors on intracranial aneurysm formation.
The influence of hemodynamic stress factors on intracranial aneurysm formation.
复制标题
血流动力学应激因素对颅内动脉瘤形成的影响。
DOI：
10.3171/jns.2001.95.5.0764
复制
发表时间：
2001
影响因子：
4.1
通讯作者：
P. Kirkpatrick
中科院分区：
文献类型：
--
作者：
C. Turner;S. Tebbs;P. Smielewski;P. Kirkpatrick
对象
压平眼压测量是一种评估外周动脉血压和中心动脉血压 (BP) 曲线的无创方法。在这项研究中，作者检查了颅内动脉瘤患者的这些特征与年龄匹配的对照组相比是否存在差异。
方法
使用脉搏波分析系统获得颈动脉 (CA) 和衍生主动脉血压波形。记录收缩压肩部以上的压力波振幅与总收缩压的比率（增强指数[AI]）。对 173 名颅内动脉瘤患者（23 个未破裂病变）和 173 名健康对照志愿者进行了检查。对于动脉瘤患者，右侧和左侧 CA AI（平均值+/-标准差）分别为 125.6 +/- 23.1% 和 128.3 +/- 22.1%。对照组的相应值为 118.4 +/- 22.6% 和 119.4 +/- 21.8%。对于动脉瘤患者和对照志愿者，计算出的升主动脉 AI 分别为 29.8 +/- 10.5% 和 25.6 +/- 12.2%。动脉瘤患者的 CA AI 存在显着不对称，左侧更大 (p = 0.002)。平均血压没有显着差异（动脉瘤患者为 108 +/- 14 mm Hg，对照组为 106 +/- 16 mm Hg；p = 0.2）。多变量分析排除了血压和其他潜在混杂血管危险因素对 AI 增加的影响。
结论
与匹配的对照组相比，颅内动脉瘤患者的 AI 在大小和对称性方面均存在显着差异。
OBJECT
Applanation tonometry is a noninvasive method of assessing both peripheral and central arterial blood pressure (BP) profiles. In this study the authors examine whether there are differences in these profiles in patients with intracranial aneurysms when compared with age-matched controls.
METHODS
Carotid artery (CA) and derived aortic BP waveforms were obtained using a pulse wave analysis system. The ratio of the pressure wave amplitude above the systolic shoulder to the total systolic BP (augmentation index [AI]) was recorded. One hundred seventy-three patients with intracranial aneurysms (23 unruptured lesions) and 173 healthy control volunteers were examined. For the patients with aneurysms the right and left CA AIs (mean +/- standard deviation) were 125.6 +/- 23.1% and 128.3 +/- 22.1%, respectively. Corresponding values for the control group were 118.4 +/- 22.6% and 119.4 +/- 21.8%. The calculated AI for the ascending aorta was 29.8 +/- 10.5% and 25.6 +/- 12.2% for patients with aneurysms and control volunteers, respectively. Significant asymmetry in CA AI was seen in patients with aneurysms, the left being greater (p = 0.002). No significant differences were seen in mean BP (108 +/- 14 mm Hg in patients with aneurysms compared with 106 +/- 16 mm Hg in controls; p = 0.2). Multivariate analysis excluded the influence of BP and other potential confounding vascular risk factors for increased AI.
CONCLUSIONS
Significant differences in AI, both in magnitude and symmetry, were identified in patients with intracranial aneurysms when compared with matched controls.
影响因子：
37.8
作者：
Chen-Huan Chen-Chen-Huan-Chen-10355153;E. Nevo;B. Fetics;P. Pak;F. Yin;W. Maughan;D. Kass
通讯作者：
Chen-Huan Chen-Chen-Huan-Chen-10355153;E. Nevo;B. Fetics;P. Pak;F. Yin;W. Maughan;D. Kass
影响因子：
158.5
作者：
Wiebers, D;Whisnant, J;Kivisaari, R
通讯作者：
Kivisaari, R
影响因子：
8.3
作者：
INGALL, TJ;WHISNANT, JP;OFALLON, WM
通讯作者：
OFALLON, WM