Adjusting for allometric scaling in ABIDE I challenges subcortical volume differences in autism spectrum disorder.
Adjusting for allometric scaling in ABIDE I challenges subcortical volume differences in autism spectrum disorder.
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DOI：
10.1002/hbm.25145
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发表时间：
2020-11
影响因子：
4.8
通讯作者：
Ramus F
中科院分区：
文献类型：
--
作者：
Williams CM;Peyre H;Toro R;Beggiato A;Ramus F
调查自闭症谱系障碍 (ASD) 皮层下相关性的研究之间的不一致可能源于样本量小、样本异质性以及忽略或线性调整总脑容量 (TBV)。为了正确调整 TBV，在检查典型发育 (TD) 和 ASD 个体之间的皮层下体积差异时，考虑了大脑异速生长（区域体积与 TBV 之间的非线性缩放关系）。自闭症脑成像数据交换 I（ABIDE I；N = 654）数据采用两种方法进行分析：单变量线性混合效应模型和多变量多组验证性因素分析。根据年龄、性别和全面智商 (FSIQ) 对整个样本和子样本进行分析。重复了类似的 ABIDE I 研究，并研究了不同 TBV 调整对神经解剖学组差异的影响。跨方法的整个样本中没有观察到明显的皮层下异速或体积组差异。探索性分析表明，异速生长缩放和体积组差异可能存在于由年龄、性别和/或 FSIQ 定义的某些亚组中。 TBV 调整的类型影响一些报告的体积和缩放组差异。这项研究支持在调整大脑异速生长时，所研究的体积中 ASD 和 TD 个体之间不存在明显的体积差异，通过发现异速生长缩放中没有组间差异来扩展文献，并进一步表明不同的 TBV 调整有助于报告的 ASD 神经解剖学差异的变异性。为了正确调整 TBV，在检查典型发育个体和 ASD 个体之间的皮层下体积差异时，考虑了大脑异速生长（区域体积与 TBV 之间的非线性缩放关系）。在单变量线性混合效应模型和多变量多组验证性因素分析中，整个样本中没有观察到稳健的皮层下异速或体积组差异。
Inconsistencies across studies investigating subcortical correlates of autism spectrum disorder (ASD) may stem from small sample size, sample heterogeneity, and omitting or linearly adjusting for total brain volume (TBV). To properly adjust for TBV, brain allometry—the nonlinear scaling relationship between regional volumes and TBV—was considered when examining subcortical volumetric differences between typically developing (TD) and ASD individuals. Autism Brain Imaging Data Exchange I (ABIDE I; N = 654) data was analyzed with two methodological approaches: univariate linear mixed effects models and multivariate multiple group confirmatory factor analyses. Analyses were conducted on the entire sample and in subsamples based on age, sex, and full scale intelligence quotient (FSIQ). A similar ABIDE I study was replicated and the impact of different TBV adjustments on neuroanatomical group differences was investigated. No robust subcortical allometric or volumetric group differences were observed in the entire sample across methods. Exploratory analyses suggested that allometric scaling and volume group differences may exist in certain subgroups defined by age, sex, and/or FSIQ. The type of TBV adjustment influenced some reported volumetric and scaling group differences. This study supports the absence of robust volumetric differences between ASD and TD individuals in the investigated volumes when adjusting for brain allometry, expands the literature by finding no group difference in allometric scaling, and further suggests that differing TBV adjustments contribute to the variability of reported neuroanatomical differences in ASD. To properly adjust for TBV, brain allometry—the nonlinear scaling relationship between regional volumes and TBV—was considered when examining subcortical volumetric differences between typically developing and ASD individuals. No robust subcortical allometric or volumetric group differences were observed in the entire sample across the univariate linear mixed effects models and the multivariate multiple group confirmatory factor analyses.
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影响因子：
4.7
作者：
Duerden, Emma G.;Mak-Fan, Kathleen M.;Roberts, S. Wendy
通讯作者：
Roberts, S. Wendy
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
4.8
作者：
de Jong, Laura W.;Vidal, Jean-Sebastien;Forsberg, Lars E.;Zijdenbos, Alex P.;Haight, Thaddeus;Sigurdsson, Sigurdur;Gudnason, Vilmundur;van Buchem, Mark A.;Launer, Lenore J.
通讯作者：
Launer, Lenore J.
影响因子：
11
作者：
Bedford, Saashi A.;Park, Min Tae M.;Chakravarty, M. Mallar
通讯作者：
Chakravarty, M. Mallar
DOI：
10.1080/10705510701301834
发表时间：
2005-01-01
影响因子：
6
作者：
Chen, FF;Sousa, KH;West, SG
通讯作者：
West, SG