Cellular self-cannibalism helps immune cells fight the flu.
Cellular self-cannibalism helps immune cells fight the flu.
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DOI:
10.1111/febs.15641
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发表时间:
2021-05
期刊:
影响因子:
--
通讯作者:
Van Kaer L
中科院分区:
文献类型:
--
作者:
Postoak JL;Yang G;Wu L;Van Kaer L
CD4 T cells are critical for generating protective immune responses to infection with influenza virus. Although most CD4 T cells react with peptides from extracellular sources, many react with peptides from viral particles synthesized inside cells, however, the pathways employed for processing the latter antigens remain uncertain. Deng et al. provide evidence for a role of autophagy, a cellular self-eating process, in this unconventional antigen processing route, with potential implications for the development of influenza virus vaccines.
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