Awareness and preferences regarding BRCA1/2 genetic counseling and testing among Latinas and non-Latina white women at increased risk for hereditary breast and ovarian cancer.
Awareness and preferences regarding BRCA1/2 genetic counseling and testing among Latinas and non-Latina white women at increased risk for hereditary breast and ovarian cancer.
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DOI：
10.1007/s10897-011-9376-7
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发表时间：
2011-12
影响因子：
1.9
通讯作者：
Kinney AY
中科院分区：
文献类型：
--
作者：
Gammon AD;Rothwell E;Simmons R;Lowery JT;Ballinger L;Hill DA;Boucher KM;Kinney AY
这项研究是对具有BRCA1/2突变风险的拉丁裔和非拉丁裔白人的遗传咨询和检测相关的意识、认知、心理社会和教育需求的调查。63名拉丁裔和84名非拉丁裔白人女性完成了电话调查，调查采用了定量和定性问题的混合，评估了对BRCA1/2测试的认识、好处、风险、障碍和遗传咨询沟通偏好。在以前没有接受过遗传咨询/检测的参与者中，56.9%的拉丁裔(29/51)和34.8%的非拉丁裔白人参与者(24/69)不知道BRCA1/2检测的可用性。在多因素Logistic回归分析中，拉丁裔是与缺乏意识相关的唯一有统计学意义的独立因素(OR=0.42；95%CI=0.19~0.35)。在BRCA1/2测试的感知益处或期望的遗传咨询主题方面，种族组之间没有明显的差异。这些发现强调了在拉丁裔和非拉丁裔白人群体中提高对癌症遗传咨询和基因测试的认识的重要性。
This study was an investigation of awareness, cognitions, and psychosocial and educational needs related to genetic counseling and testing among Latinas and non-Latina whites at increased risk for having a BRCA1/2 mutation. Sixty-three Latina and eighty-four non-Latina white women completed telephone surveys employing a mixture of quantitative and qualitative questions assessing awareness, benefits, risks, barriers, and genetic counseling communication preferences regarding BRCA1/2 testing. Among participants who had not previously had genetic counseling/testing, 56.9% of Latinas (29/51) and 34.8% of non-Latina white participants (24/69) were unaware of the availability of BRCA1/2 testing. In multivariate logistic regression analysis, Latina ethnicity was the only statistically significant independent factor associated with lack of awareness (OR=0.42; 95% CI=0.19–0.35). No appreciable differences were noted between ethnic groups regarding perceived benefits of BRCA1/2 testing or desired genetic counseling topics. These findings underscore the importance of increasing awareness of cancer genetic counseling and genetic testing among both Latina and non-Latina white populations.
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影响因子：
5.4
作者：
Bates, BR;Lynch, JA;Condit, CA
通讯作者：
Condit, CA
影响因子：
1.7
作者：
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
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1995-01-01
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