Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models.
Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models.
复制标题
啮齿动物模型异位部分心脏移植的发病率和死亡率
DOI：
10.3390/jcdd10060234
复制
发表时间：
2023-05-26
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
作者：
不可修复的先天性心脏瓣膜疾病是小儿心脏手术中一个尚未解决的问题，因为没有生长的心脏瓣膜植入物。部分心脏移植就是旨在解决这一问题的新型移植。为了研究部分心脏移植独特的移植生物学，动物模型是必要的。本研究旨在评估啮齿动物模型中异位部分心脏移植的发病率和死亡率。这项研究评估了两种模型。第一个模型涉及将供体动物的心脏瓣膜移植到受体动物的腹主动脉位置。第二种模型涉及将心脏瓣膜小叶移植到受体动物的肾被膜下位置。总共 33 只动物在腹主动脉位置接受了异位部分心脏移植。该模型的结果发现，术中死亡率为 60.61% (n = 20/33)，围手术期死亡率为 39.39% (n = 13/33)。术中死亡率是由于手术引起的血管并发症，围手术期死亡率是由于移植物血栓形成。总共33只动物在肾被膜下位置接受了异位部分心脏移植。该模型的结果发现，术中死亡率为 3.03%（n = 1/33），其余 96.97% 存活（n = 32/33）。我们的结论是，肾被膜下模型的死亡率较低，并且在技术上比腹主动脉模型更容易获得。虽然将瓣膜异位移植到腹主动脉位置在啮齿动物模型中具有显着的发病率和死亡率，但肾包膜下模型为成功异位移植提供了证据。
Unrepairable congenital heart valve disease is an unsolved problem in pediatric cardiac surgery because there are no growing heart valve implants. Partial heart transplantation is a new type of transplant that aims to solve this problem. In order to study the unique transplant biology of partial heart transplantation, animal models are necessary. This study aimed to assess the morbidity and mortality of heterotopic partial heart transplantation in rodent models. This study assessed two models. The first model involved transplanting heart valves from donor animals into the abdominal aortic position in the recipient animals. The second model involved transplanting heart valve leaflets into the renal subcapsular position of the recipient animals. A total of 33 animals underwent heterotopic partial heart transplantation in the abdominal aortic position. The results of this model found a 60.61% (n = 20/33) intraoperative mortality rate and a 39.39% (n = 13/33) perioperative mortality rate. Intraoperative mortality was due to vascular complications from the procedure, and perioperative mortality was due to graft thrombosis. A total of 33 animals underwent heterotopic partial heart transplantation in the renal subcapsular position. The results of this model found a 3.03% (n = 1/33) intraoperative mortality rate, and the remaining 96.97% survived (n = 32/33). We conclude that the renal subcapsular model has a lower mortality rate and is technically more accessible than the abdominal aortic model. While the heterotopic transplantation of valves into the abdominal aortic position had significant morbidity and mortality in the rodent model, the renal subcapsular model provided evidence for successful heterotopic transplantation.
登录
查看更多内容
DOI：
10.1002/cnm.3638
发表时间：
2022-10
影响因子：
2.1
作者：
Tobin, Nicolas;Manning, Keefe B.
通讯作者：
Manning, Keefe B.
DOI：
10.1016/s0022-5223(03)00116-8
发表时间：
2003-07-01
影响因子：
6
作者：
Hawkins, JA;Hillman, ND;Shaddy, RE
通讯作者：
Shaddy, RE
影响因子：
3.1
作者：
Cupitra, Nelson Ivan;Leon-Rodriguez, Jimmy;Narvaez-Sanchez, Raul
通讯作者：
Narvaez-Sanchez, Raul
影响因子：
4.6
作者：
Nelson, Jennifer S.;Pasquali, Sara K.;Hirsch-Romano, Jennifer C.
通讯作者：
Hirsch-Romano, Jennifer C.
影响因子：
4.6
作者：
Rajab, Taufiek Konrad;Zorrilla-Vaca, Andres;Sainathan, Sandeep
通讯作者：
Sainathan, Sandeep