Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.
Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.
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DOI：
10.1002/cnm.3638
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发表时间：
2022-10
影响因子：
2.1
通讯作者：
Manning, Keefe B.
中科院分区：
文献类型：
--
作者：
Tobin, Nicolas;Manning, Keefe B.
血栓形成和血栓栓塞是血液接触生物医学设备中的致命危险因素，尽管血栓栓塞的模拟仍然不发达，但血栓形成的计算机模型是了解这些过程机制的有吸引力的工具。本研究的目的是修改现有的计算血栓形成模型以允许血栓栓塞，并研究修改后的模型在一定流速范围内的行为。据观察，新模型和现有模型在跨流速的规范向后台阶几何形状中导致了类似的血栓形成预测，并且两个模型都不能预测湍流中的血栓形成。在较低流量下形成凝块以诱导栓塞的情况下，通过增加流速来进行模拟。虽然观察到栓塞，但大多数凝块分解是通过剪切而不是通过凝结材料的破碎和随后的运输，并且在栓塞的制定和验证方面需要进一步的工作。该模型为进一步研究血栓栓塞提供了框架。
Thrombosis and thromboembolism are deadly risk factors in blood-contacting biomedical devices, and in-silico models of thrombosis are attractive tools to understand the mechanics of these processes, though the simulation of thromboembolism remains underdeveloped. The purpose of this study is to modify an existing computational thrombosis model to allow for thromboembolism and to investigate the behavior of the modified model at a range of flow rates. The new and existing models are observed to lead to similar predictions of thrombosis in a canonical backward-facing step geometry across flow rates, and neither model predicts thrombosis in a turbulent flow. Simulations are performed by increasing flow rates in the case of a clot formed at lower flow to induce embolization. While embolization is observed, most of the clot breakdown is by shear rather than by breakup and subsequent transport of clotted material, and further work is required in the formulation and validation of embolization. This model provides a framework to further investigate thromboembolization.
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