Current concepts in neuroendocrine disruption.
Current concepts in neuroendocrine disruption.
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神经内分泌干扰的当前概念。
DOI：
10.1016/j.ygcen.2014.02.005
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发表时间：
2014-07-01
影响因子：
2.7
通讯作者：
Trudeau VL
中科院分区：
文献类型：
--
作者：
León-Olea M;Martyniuk CJ;Orlando EF;Ottinger MA;Rosenfeld C;Wolstenholme J;Trudeau VL
在过去的几年中，人们已经清楚地认识到，各种各样的环境污染物对鱼类、两栖动物、鸟类和哺乳动物的神经内分泌系统具有特定的影响。虽然这是超出了本审查的范围，提供所有这些神经内分泌干扰物的全面检查，我们将集中在选择有代表性的例子。有机氯农药在直接调节GnRH神经元的大脑神经内分泌区域中生物累积，从而改变GnRH信号下游基因的表达。有机氯农药还可以激动或拮抗激素受体，对神经递质系统之间的串扰产生不利影响。多氯联苯的影响多种多样，在许多情况下是微妙的。这对于暴露的神经内分泌和行为影响尤其如此。这些效应影响下丘脑-垂体-性腺轴的性分化，以及调节甲状腺、代谢和应激轴及其生理反应的其他神经内分泌系统。弱雌激素和抗雄激素污染物，如双酚A，邻苯二甲酸酯，植物化学物质和杀菌剂乙烯唑啉，可导致严重和广泛的神经内分泌干扰离散的大脑区域，包括海马体，杏仁核和下丘脑，导致行为的变化，在广泛的物种。已被证明受一种或多种这些化学物质影响的行为特征包括认知缺陷，焦虑或焦虑样，社会性行为，运动和食欲行为。神经活性药物现在通过废水处理厂排放物的释放在水生环境和供水中被广泛检测到。抗抑郁药氟西汀就是这样一种药物神经内分泌干扰物。氟西汀是一种选择性5-羟色胺再摄取抑制剂，可影响多种神经内分泌通路和行为回路，包括对鱼类生殖和摄食的破坏性影响。越来越多的证据表明，环境污染物暴露与具有强烈神经内分泌成分的疾病之间存在关联，例如生殖力下降、神经变性和心脏病。考虑神经内分泌干扰物暴露的时间至关重要，因为中枢神经系统发育的胚胎阶段对不良影响非常敏感。还有证据表明，某些污染物具有表观遗传和跨代神经内分泌干扰效应。我们现在必须考虑神经内分泌干扰物对生殖，发育，生长和行为的影响，以及在日益污染的世界中进化变化的人口后果。本文审查了迄今为止的证据表明，各种所谓的神经内分泌干扰物可以引起这种影响，往往在环境相关的浓度。
In the last few years, it has become clear that a wide variety of environmental contaminants have specific effects on neuroendocrine systems in fish, amphibians, birds and mammals. While it is beyond the scope of this review to provide a comprehensive examination of all of these neuroendocrine disruptors, we will focus on select representative examples. Organochlorine pesticides bioaccumulate in neuroendocrine areas of the brain that directly regulate GnRH neurons, thereby altering the expression of genes downstream of GnRH signaling. Organochlorine pesticides can also agonize or antagonize hormone receptors, adversely affecting crosstalk between neurotransmitter systems. The impacts of polychlorinated biphenyls are varied and in many cases subtle. This is particularly true for neuroedocrine and behavioral effects of exposure. These effects impact sexual differentiation of the hypothalamic-pituitary-gonadal axis, and other neuroendocrine systems regulating the thyroid, metabolic, and stress axes and their physiological responses. Weakly estrogenic and anti-androgenic pollutants such as bisphenol A, phthalates, phytochemicals, and the fungicide vinclozolin can lead to severe and widespread neuroendocrine disruptions in discrete brain regions, including the hippocampus, amygdala, and hypothalamus, resulting in behavioral changes in a wide range of species. Behavioral features that have been shown to be affected by one or more these chemicals include cognitive deficits, heightened anxiety or anxiety-like, sociosexual, locomotor, and appetitive behaviors. Neuroactive pharmaceuticals are now widely detected in aquatic environments and water supplies through the release of wastewater treatment plant effluents. The antidepressant fluoxetine is one such pharmaceutical neuroendocrine disruptor. Fluoxetine is a selective serotonin reuptake inhibitor that can affect multiple neuroendocrine pathways and behavioral circuits, including disruptive effects on reproduction and feeding in fish. There is growing evidence for the association between environmental contaminant exposures and diseases with strong neuroendocrine components, for example decreased fecundity, neurodegeneration, and cardiac disease. It is critical to consider the timing of exposures of neuroendocrine disruptors because embryonic stages of central nervous system development are exquisitely sensitive to adverse effects. There is also evidence for epigenetic and transgenerational neuroendocrine disrupting effects of some pollutants. We must now consider the impacts of neuroendocrine disruptors on reproduction, development, growth and behaviors, and the population consequences for evolutionary change in an increasingly contaminated world. This review examines the evidence to date that various so-called neuroendocrine disruptors can induce such effects often at environmentally-relevant concentrations.
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影响因子：
64.5
作者：
Ashe A;Sapetschnig A;Weick EM;Mitchell J;Bagijn MP;Cording AC;Doebley AL;Goldstein LD;Lehrbach NJ;Le Pen J;Pintacuda G;Sakaguchi A;Sarkies P;Ahmed S;Miska EA
通讯作者：
Miska EA
影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
9.9
作者：
Benarroch, Eduardo E.
通讯作者：
Benarroch, Eduardo E.
影响因子：
10.1
作者：
BORTONE, SA;DAVIS, WP
通讯作者：
DAVIS, WP
影响因子：
3.8
作者：
Bemis, JC;Seegal, RF
通讯作者：
Seegal, RF