Prenatal bisphenol A exposure and early childhood behavior.
Prenatal bisphenol A exposure and early childhood behavior.
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DOI：
10.1289/ehp.0900979
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发表时间：
2009-12
影响因子：
10.4
通讯作者：
Lanphear BP
中科院分区：
文献类型：
--
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
产前暴露于双酚A（BPA）增加后代的攻击性，减少啮齿动物性二态行为的差异。我们研究了产前BPA暴露与2岁儿童行为之间的关系。我们使用了来自辛辛那提，俄亥俄州（美国）的249名母亲和她们的孩子的数据。在妊娠16周和26周以及出生时采集母体尿液。BPA浓度采用高效液相色谱-同位素稀释串联质谱法进行定量。在2岁时使用第二版儿童行为评估系统（BASC-2）评估儿童行为。使用线性回归分析产前BPA浓度和BASC-2评分之间的关联。中位BPA浓度为1.8（16周），1.7（26周）和1.3（出生）ng/mL。平均（± SD）BASC-2外化和内化评分分别为47.6 ± 7.8和44.8 ± 7.0。校正混杂因素后，log 10转换的平均产前BPA浓度与外化评分相关，但仅在女性中[β = 6.0; 95%置信区间（CI），0.1-12.0]。与26周和出生时的浓度相比，在所有儿童中，16周左右收集的BPA浓度与外化评分的相关性更强（β = 2.9; 95% CI，0.2-5.7），女性的相关性比男性更强。在所有儿童中，在≤ 16周时收集的测量结果显示，与17-21周时收集的测量结果相比（β = 0.6; 95%CI，-2.9至4.1），与外部化评分的关联更强（β = 5.1; 95%CI，1.5-8.6）。这些结果表明，产前BPA暴露可能与2岁儿童的外化行为有关，尤其是女童。
Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. We examined the association between prenatal BPA exposure and behavior in 2-year-old children. We used data from 249 mothers and their children in Cincinnati, Ohio (USA). Maternal urine was collected around 16 and 26 weeks of gestation and at birth. BPA concentrations were quantified using high-performance liquid chromatography–isotope-dilution tandem mass spectrometry. Child behavior was assessed at 2 years of age using the second edition of the Behavioral Assessment System for Children (BASC-2). The association between prenatal BPA concentrations and BASC-2 scores was analyzed using linear regression. Median BPA concentrations were 1.8 (16 weeks), 1.7 (26 weeks), and 1.3 (birth) ng/mL. Mean (± SD) BASC-2 externalizing and internalizing scores were 47.6 ± 7.8 and 44.8 ± 7.0, respectively. After adjustment for confounders, log10-transformed mean prenatal BPA concentrations were associated with externalizing scores, but only among females [β = 6.0; 95% confidence interval (CI), 0.1–12.0]. Compared with 26-week and birth concentrations, BPA concentrations collected around 16 weeks were more strongly associated with externalizing scores among all children (β = 2.9; 95% CI, 0.2–5.7), and this association was stronger in females than in males. Among all children, measurements collected at ≤ 16 weeks showed a stronger association (β = 5.1; 95% CI, 1.5–8.6) with externalizing scores than did measurements taken at 17–21 weeks (β = 0.6; 95% CI, −2.9 to 4.1). These results suggest that prenatal BPA exposure may be associated with externalizing behaviors in 2-year-old children, especially among female children.
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新生儿重症监护室早产儿接触双酚A和其他酚类物质。
影响因子：
10.4
作者：
Calafat, Antonia M.;Weuve, Jennifer;Ye, Xiaoyun;Jia, Lily T.;Hu, Howard;Ringer, Steven;Huttner, Ken;Hauser, Russ
通讯作者：
Hauser, Russ
DOI：
10.1080/02652030210134236
发表时间：
2003-07-01
期刊：
FOOD ADDITIVES AND CONTAMINANTS
影响因子：
--
作者：
Brede, C;Fjeldal, P;Herikstad, H
通讯作者：
Herikstad, H
影响因子：
2.9
作者：
Fujimoto, T;Kubo, K;Aou, S
通讯作者：
Aou, S
影响因子：
7.7
作者：
Greenland, S;Brumback, B
通讯作者：
Brumback, B
影响因子：
10.4
作者：
Farabollini, Francesca;Porrini, Stefania;Della Seta, Daniele;Bianchi, Fiorella;Dessi-Fulgheri, Francesco
通讯作者：
Dessi-Fulgheri, Francesco