Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.
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DOI：
10.4049/jimmunol.181.11.7728
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发表时间：
2008-12-01
期刊：
影响因子：
--
通讯作者：
Adler AJ
中科院分区：
文献类型：
--
作者：
Bandyopadhyay S;Long M;Qui HZ;Hagymasi AT;Slaiby AM;Mihalyo MA;Aguila HL;Mittler RS;Vella AT;Adler AJ
We compared how CD4 vs CD8 cells attain the capacity to express the effector cytokine IFN-γ under both immunogenic and tolerogenic conditions. Although the Ifng gene locus was epigenetically repressed in naive Ag-inexperienced CD4 cells, it had already undergone partial remodeling toward a transcriptionally competent configuration in naive CD8 cells. After TCR stimulation, CD8 cells fully remodeled the Ifng locus and gained the capacity to express high levels of IFN-γ more rapidly than CD4 cells. Enforced dual costimulation through OX40 and 4-1BB redirected CD8 cells encountering soluble exogenous peptide to expand and differentiate into IFN-γ and TNF-α double-producing effectors rather than becoming tolerant. Despite this and the stronger tendency of CD8 compared with CD4 cells to differentiate into IFN-γ-expressing effectors, when parenchymal self-Ag was the source of tolerizing Ag, enforced dual costimulation selectively boosted expansion but did not push effector differentiation in CD8 cells while both expansion and effector differentiation were dramatically boosted in CD4 cells. Notably, enforced dual costimulation was able to push effector differentiation in CD8 cells encountering cognate parenchymal self-Ag when CD4 cells were simultaneously engaged. Thus, the ability of enforced OX40 plus 4-1BB dual costimulation to redirect CD8 cells to undergo effector differentiation was unexpectedly influenced by the source of tolerizing Ag and help was selectively required to facilitate CD8 cell effector differentiation when the tolerizing Ag derived from self.
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T细胞重新进入成人胸腺，仅限于活化的T细胞。
DOI：
10.1084/jem.173.5.1039
发表时间：
1991-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Agus DB;Surh CD;Sprent J
通讯作者：
Sprent J
影响因子：
4.4
作者：
Cho, JY;Grigura, V;Murphy, K
通讯作者：
Murphy, K
影响因子：
6.4
作者：
Cuadros, C;Dominguez, AL;Lustgarten, J
通讯作者：
Lustgarten, J
影响因子：
30.5
作者：
Avni, O;Lee, D;Rao, A
通讯作者：
Rao, A
影响因子：
32.4
作者：
Bird, JJ;Brown, DR;Reiner, SL
通讯作者：
Reiner, SL