Nonlinear Effects of Noxious Thermal Stimulation and Working Memory Demands on Subjective Pain Perception.
Nonlinear Effects of Noxious Thermal Stimulation and Working Memory Demands on Subjective Pain Perception.
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DOI：
10.1111/pme.12774
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发表时间：
2015-07
期刊：
影响因子：
3.1
通讯作者：
Mackey, Sean C.
中科院分区：
文献类型：
--
作者：
Sturgeon, John A.;Tieu, Meghan M.;Jastrzab, Laura E.;McCue, Rebecca;Gandhi, Vanisha;Mackey, Sean C.
长期以来，人们一直认为工作记忆和急性疼痛之间存在双向关系，但存在关于这种关系的模棱两可的证据。目前的研究描述了使用适应的Sternberg工作记忆任务的健康人的工作记忆和急性疼痛处理之间的关系。参与者在接受有害的热刺激的同时完成了一项Sternberg任务。参与者收到了4种不同温度(基线温度和单独确定的低、中、高温刺激)和4个Sternberg任务难度水平(0、3、6和9个字母串)的伪随机演示。从斯坦福大学和周围社区招募了28名健康参与者来完成当前的研究。热刺激强度与Sternberg任务难度之间存在非线性交互作用。来自Sternberg任务的认知负荷增加导致对低强度热刺激的痛觉增加，但抑制了高强度热刺激的痛觉。热刺激对参与者在Sternberg任务中的反应时间或准确性没有显著影响，无论强度水平如何。疼痛感觉似乎是工作记忆负荷的函数，只有在足够有害的刺激下才会减少。然而，增加伤害性刺激并不影响认知表现。这些复杂的关系可能反映了一个共享的认知空间，可能会因足够强度的多个刺激输入而变得“超负荷”。
A bi-directional relationship between working memory and acute pain has long been assumed, but equivocal evidence exists regarding this relationship. The current study characterized the relationship between working memory and acute pain processing in healthy individuals using an adapted Sternberg working memory task. Participants completed a Sternberg task while receiving noxious thermal stimulation. Participants received a pseudo-random presentation of 4 different temperatures (baseline temperatures and individually-determined low-, medium-, and high-temperature stimuli) and 4 levels of Sternberg task difficulty (0-, 3-, 6-, and 9-letter strings). 28 healthy participants were recruited from Stanford University and the surrounding community to complete the current study. A non-linear interaction between intensity of thermal stimulation and difficulty of the Sternberg task was noted. Increased cognitive load from the Sternberg task resulted in increased perception of pain in low-intensity thermal stimulation but suppressed pain perception in high-intensity thermal stimulation. Thermal stimulation had no significant effect on participants’ response time or accuracy on the Sternberg task regardless of intensity level. Pain perception appears to decrease as a function of working memory load only for sufficiently noxious stimuli. However, increasing noxious stimuli did not affect cognitive performance. These complex relationships may reflect a shared cognitive space that can become “overloaded” with input of multiple stimuli of sufficient intensity.
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影响因子：
14.5
作者：
Bantick, SJ;Wise, RG;Tracey, I
通讯作者：
Tracey, I
影响因子：
4.2
作者：
Cole, Leonie J.;Farrell, Michael J.;Egan, Gary F.
通讯作者：
Egan, Gary F.
DOI：
10.1073/pnas.96.14.7705
发表时间：
1999-07-06
影响因子：
11.1
作者：
Bushnell, MC;Duncan, GH;Carrier, B
通讯作者：
Carrier, B
影响因子：
7.4
作者：
Moore, David J.;Keogh, Edmund;Eccleston, Christopher
通讯作者：
Eccleston, Christopher
DOI：
10.1016/s1090-3801(99)90014-9
发表时间：
1999-01-01
期刊：
EUROPEAN JOURNAL OF PAIN-LONDON
影响因子：
--
作者：
Grisart, JM;Plaghki, LH
通讯作者：
Plaghki, LH