Cannabinoid receptors mediate methamphetamine induction of high frequency gamma oscillations in the nucleus accumbens.
Cannabinoid receptors mediate methamphetamine induction of high frequency gamma oscillations in the nucleus accumbens.
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DOI：
10.1016/j.neuropharm.2012.04.036
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发表时间：
2012-09
影响因子：
4.7
通讯作者：
Cheer JF
中科院分区：
文献类型：
--
作者：
Morra JT;Glick SD;Cheer JF
患有安非他明引起的精神病的患者表现出重复的行为，抗精神病药物部分缓解了这些行为，这些行为使人想起啮齿类动物的刻板印象。由于最近有证据表明内源性大麻素与包括精神病在内的脑部疾病有关，我们研究了内源性大麻素信号传导对表现甲基苯丙胺刻板印象的大鼠神经元振荡的影响。用多个单电极阵列对准自由运动的大鼠伏隔核记录神经元网络振荡。在实验过程中，动物被静脉注射CB1受体拮抗剂利莫那班（0.3 mg/kg）或对照物，随后甲基苯丙胺（0.01、0.1、1和3 mg/kg；累积剂量）的剂量递增。评估了药物给药对刻板印象和局部伽马振荡的影响。甲基苯丙胺治疗显著增加高频振荡（~ 80 Hz）。伏隔核神经元亚群对高频伽马的携带与假定的快速尖峰中间神经元的刻板印象编码有关，但与假定的中棘神经元无关。观察到的甲基苯丙胺诱导定型和高频伽马功率的能力在CB1受体阻断后被严重破坏。目前的数据表明，甲基苯丙胺可以利用CB1受体依赖机制来改变纹状体神经元间振荡，这种振荡伴随着精神运动状态的变化，进一步支持内源性大麻素与精神分裂症谱系障碍之间的联系。
Patients suffering from amphetamine---induced psychosis display repetitive behaviors, partially alleviated by antipsychotics, which are reminiscent of rodent stereotypies. Due to recent evidence implicating endocannabinoid involvement in brain disorders, including psychosis, we studied the effects of endocannabinoid signaling on neuronal oscillations of rats exhibiting methamphetamine stereotypy. Neuronal network oscillations were recorded with multiple single electrode arrays aimed at the nucleus accumbens of freely moving rats. During the experiments, animals were dosed intravenously with the CB1 receptor antagonist rimonabant (0.3 mg/kg) or vehicle followed by an ascending dose regimen of methamphetamine (0.01, 0.1, 1, and 3 mg/kg; cumulative dosing). The effects of drug administration on stereotypy and local gamma oscillations were evaluated. Methamphetamine treatment significantly increased high frequency gamma oscillations (~ 80 Hz). Entrainment of a subpopulation of nucleus accumbens neurons to high frequency gamma was associated with stereotypy encoding in putative fast-spiking interneurons, but not in putative medium spiny neurons. The observed ability of methamphetamine to induce both stereotypy and high frequency gamma power was potently disrupted following CB1 receptor blockade. The present data suggest that CB1 receptor-dependent mechanisms are recruited by methamphetamine to modify striatal interneuron oscillations that accompany changes in psychomotor state, further supporting the link between endocannabinoids and schizophrenia spectrum disorders.
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影响因子：
3.7
作者：
Hakami T;Jones NC;Tolmacheva EA;Gaudias J;Chaumont J;Salzberg M;O'Brien TJ;Pinault D
通讯作者：
Pinault D
DOI：
10.1523/jneurosci.5335-09.2010
发表时间：
2010-04-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Morra JT;Glick SD;Cheer JF
通讯作者：
Cheer JF
影响因子：
3.4
作者：
Martin, RS;Secchi, RL;Lowe, DA
通讯作者：
Lowe, DA
影响因子：
25
作者：
Gerdeman, GL;Ronesi, J;Lovinger, DM
通讯作者：
Lovinger, DM
影响因子：
3
作者：
Masimore, B;Kakalios, J;Redish, AD
通讯作者：
Redish, AD