Asthma and obesity: mechanisms and clinical implications
Asthma and obesity: mechanisms and clinical implications
复制标题
哮喘和肥胖：机制和临床意义
作者：
C. Baffi;D. Winnica;F. Holguin
肥胖是最常见的哮喘合并症;它与哮喘急性发作、呼吸道症状恶化和控制不良的风险增加有关。确切的机制仍然难以捉摸，可能是多因素的，从气道和肺实质的机械改变，到全身和气道炎症和代谢失调，对肺功能和/或对治疗的反应产生不利影响。然而，并非每一个肥胖哮喘患者都受到体重增加的影响，这一事实凸显了理解这种关联的许多挑战和复杂性。决定易感性的因素可能不仅仅取决于肥胖，而是与其他表型特征的相互作用，例如哮喘发作的年龄，性别和种族等等。无法解释哮喘表型受体重指数（BMI）增加的不同影响，可能导致研究结果缺乏一致性。这篇综述将提供一个简洁的总结，肥胖相关的机制和临床影响哮喘，包括突出的最新进展。
Obesity is the most common asthma co-morbidity; it has been associated with increased risk for asthma exacerbations, worse respiratory symptoms and poor control. The exact mechanisms remain elusive and are probably multifactorial, stemming from mechanical alterations of the airways and lung parenchyma, to systemic and airway inflammatory and metabolic dysregulation that adversely influences lung function and or response to therapy. However, the fact that not every obese asthmatic is equally affected by weight gain highlights the many challenges and complexities in understanding this association. The factors that determine susceptibility may not depend on being obese alone, but rather the interactions with other phenotypical characteristics, such as age of asthma onset, gender and race to name a few. Inability to account for asthma phenotypes that are differentially affected by increasing body mass index (BMI) may contribute to the lack of consistent results across studies. This review will provide a succinct summary of obesity-related mechanisms and the clinical impact on asthma including highlights on recent progress.
登录
查看更多内容
DOI：
10.1164/rccm.201203-0573oc
发表时间：
2012-10-01
影响因子：
24.7
作者：
Sideleva, Olga;Suratt, Benjamin T.;Dixon, Anne E.
通讯作者：
Dixon, Anne E.
DOI：
10.1016/j.jaci.2011.06.009
发表时间：
2011-09
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Dixon AE;Pratley RE;Forgione PM;Kaminsky DA;Whittaker-Leclair LA;Griffes LA;Garudathri J;Raymond D;Poynter ME;Bunn JY;Irvin CG
通讯作者：
Irvin CG
哮喘不受控制的成人的腹部和全身肥胖以及哮喘控制水平。
影响因子：
8.3
作者：
Lv,Nan;Xiao,Lan;CamargoJr,CarlosA;Wilson,SandraR;Buist,ASonia;Strub,Peg;Nadeau,KariC;Ma,Jun
通讯作者：
Ma,Jun
DOI：
10.1164/rccm.200808-1361oc
发表时间：
2009-05-01
影响因子：
24.7
作者：
Brehm, John M.;Celedon, Juan C.;Litonjua, Augusto A.
通讯作者：
Litonjua, Augusto A.
DOI：
10.1164/rccm.200906-0896oc
发表时间：
2010-02-15
影响因子：
24.7
作者：
Moore, Wendy C.;Meyers, Deborah A.;Bleecker, Eugene R.
通讯作者：
Bleecker, Eugene R.