Delineating the impact of COVID-19 on antimicrobial resistance: An Indian perspective.

Delineating the impact of COVID-19 on antimicrobial resistance: An Indian perspective.
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DOI:
10.1016/j.scitotenv.2021.151702
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发表时间:
2022-04-20
期刊:
The Science of the total environment
影响因子:
--
通讯作者:
Selvin J
Selvin J
中科院分区:
其他
文献类型:
--
作者:
Seethalakshmi PS;Charity OJ;Giakoumis T;Kiran GS;Sriskandan S;Voulvoulis N;Selvin J

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COVID-19疫情已摧毁全球数百万人的生命,并因出现令人担忧的变种而继续对公共卫生构成挑战。对COVID-19后继发感染的恐惧导致大流行期间抗菌药物的使用升级,而一些抗菌药物已被重新用于SARS-CoV-2的治疗,进一步推动了抗菌药物耐药性。印度是全球最大的抗生素生产国和消费国之一,因此遏制抗生素耐药性的任务是一项巨大的挑战。经验性抗菌药物处方和临床环境中药物的再利用、自我药疗和过度使用抗菌卫生产品等做法可能对印度抗菌药物耐药性的流行产生负面影响。然而,在大流行期间,为应对需求增加而扩大了抗菌剂和消毒剂的生产,可能通过对环境的重大影响,对抗菌剂耐药性的威胁产生了更大的影响。该综述概述了COVID-19对临床环境中抗菌素耐药性的影响以及对环境的可能后果。该综述呼吁升级现有的抗菌药物政策,并强调需要进行研究,以了解印度大流行对抗菌药物耐药性的影响。
The COVID-19 pandemic has shattered millions of lives globally and continues to be a challenge to public health due to the emergence of variants of concern. Fear of secondary infections following COVID-19 has led to an escalation in antimicrobial use during the pandemic, while some antimicrobials have been repurposed as treatments for SARS-CoV-2, further driving antimicrobial resistance. India is one of the largest producers and consumers of antimicrobials globally, hence the task of curbing antimicrobial resistance is a huge challenge. Practices like empirical antimicrobial prescription and repurposing of drugs in clinical settings, self-medication and excessive use of antimicrobial hygiene products may have negatively impacted the prevalence of antimicrobial resistance in India. However, the expanded production of antimicrobials and disinfectants during the pandemic in response to increased demand may have had an even greater impact on the threat of antimicrobial resistance through major impacts on the environment. The review provides an outline of the impact COVID-19 can have on antimicrobial resistance in clinical settings and the possible outcomes on the environment. This review calls for the upgrading of existing antimicrobial policies and emphasizes the need for research studies to understand the impact of the pandemic on antimicrobial resistance in India.
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