Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans.

Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans.
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建立刻板连接:对线虫结构可塑性的机械见解。

DOI:
10.1016/j.conb.2017.11.005
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发表时间:
2018-03
影响因子:
5.7
通讯作者:
Qi YB
Qi YB
中科院分区:
医学2区
文献类型:
--
作者:
Jin Y;Qi YB

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神经元修改或重塑其突触连接的能力对于动物一生中神经回路的功能至关重要。了解神经元结构变化的机制对于我们了解神经系统如何形成复杂行为以及如何进一步适应发育和环境需求至关重要。秀丽隐杆线虫为研究发育过程和发现控制神经可塑性的机制提供了一个强有力的模型。最近的研究结果已经确定了保守的主题神经可塑性的发展和环境压力下。
The ability of neurons to modify or remodel their synaptic connectivity is critical for the function of neural circuitry throughout the life of an animal. Understanding the mechanisms underlying neuronal structural changes is central to our knowledge of how the nervous system is shaped for complex behaviors and how it further adapts to developmental and environmental demands. Caenorhabditis elegans provides a powerful model for examining developmental processes and for discovering mechanisms controlling neural plasticity. Recent findings have identified conserved themes underlying neural plasticity in development and under environmental stress.
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