Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions.
Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions.
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临床翻译的二氧化硅纳米颗粒作为以癌为标志性的探针进行图像引导的手术和干预措施。
DOI：
10.1039/c2ib20174g
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Patel S
中科院分区：
文献类型：
--
作者：
Bradbury MS;Phillips E;Montero PH;Cheal SM;Stambuk H;Durack JC;Sofocleous CT;Meester RJ;Wiesner U;Patel S
黑色素瘤的早期诊断和治疗对于降低发病率和死亡率至关重要。淋巴结转移的存在是一个重要的预后预测因子，通过影像学准确识别对疾病分期、预后和临床结果具有重要意义。前哨淋巴结（SLN）标测程序受到缺乏术中可视化工具的限制，这些工具可以帮助准确确定疾病扩散并从相邻的重要神经和血管结构中勾画出淋巴结。规避这些问题的较新方法可以利用各种成像工具，包括与便携式设备技术结合使用的生物相容性颗粒平台，用于图像引导的外科手术和介入手术。我们在本文中描述了一种用于PET和光学成像的临床转化的整合素靶向平台，其满足用于改善SLN组织定位和保留、靶与背景比以及从注射部位和身体的清除的许多关键设计标准。使用这些药物选择性地探测关键的癌症靶点可能会阐明对控制转移性疾病扩散的细胞和分子过程的重要见解。结合便携式实时光学摄像系统，我们表明，术前PET成像结果映射转移性疾病在临床相关的大型动物模型可以很容易地转化为术中设置引流肿瘤血管和荧光SLN/s与组织学相关的直接可视化。该平台相对于标准放射性示踪剂18F-FDG的特异性，用于潜在区分转移性疾病与炎症过程，也在基于药物或介入驱动的治疗中进行了讨论。
Early diagnosis and treatment of melanoma are essential to minimizing morbidity and mortality. The presence of lymph node metastases is a vital prognostic predictor, and accurate identification by imaging has important implications for disease staging, prognosis, and clinical outcome. Sentinel lymph node (SLN) mapping procedures are limited by a lack of intraoperative visualization tools that can aid accurate determination of disease spread and delineate nodes from adjacent critical neural and vascular structures. Newer methods for circumventing these issues can exploit a variety of imaging tools, including biocompatible particle-based platforms coupled with portable device technologies for use with image-guided surgical and interventional procedures. We describe herein a clinically-translated, integrin-targeting platform for use with both PET and optical imaging that meets a number of key design criteria for improving SLN tissue localization and retention, target-to-background ratios, and clearance from the site of injection and the body. The use of such agents for selectively probing critical cancer targets may elucidate important insights into cellular and molecular processes that govern metastatic disease spread. Coupled with portable, real-time optical camera systems, we show that pre-operative PET imaging findings for mapping metastatic disease in clinically-relevant larger-animal models can be readily translated into the intraoperative setting for direct visualization of the draining tumor lymphatics and fluorescent SLN/s with histologic correlation. The specificity of this platform, relative to the standard-of-care radiotracer, 18F-FDG, for potentially discriminating metastatic disease from inflammatory processes is also discussed in the setting of surgically-based or interventionally-driven therapies.
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影响因子：
3.1
作者：
Keereweer, Stijn;Kerrebijn, Jeroen D. F.;van Driel, Pieter B. A. A.;Xie, Bangwen;Kaijzel, Eric L.;Snoeks, Thomas J. A.;Que, Ivo;Hutteman, Merlijn;van der Vorst, Joost R.;Mieog, J. Sven D.;Vahrmeijer, Alexander L.;van de Velde, Cornelis J. H.;de Jong, Robert J. Baatenburg;Lowik, Clemens W. G. M.
通讯作者：
Lowik, Clemens W. G. M.
影响因子：
--
作者：
Amersi, Farin F.;McElrath-Garza, Ana;Bilchik, Anton J.
通讯作者：
Bilchik, Anton J.
影响因子：
10.6
作者：
Anderson, GS;Brinkmann, F;Zhuang, HM
通讯作者：
Zhuang, HM
影响因子：
5
作者：
Barker, DW;Zagoria, RJ;Shen, P
通讯作者：
Shen, P
影响因子：
10.8
作者：
Burns AA;Vider J;Ow H;Herz E;Penate-Medina O;Baumgart M;Larson SM;Wiesner U;Bradbury M
通讯作者：
Bradbury M