Mechanisms and pathogenesis of chronic rhinosinusitis.
Mechanisms and pathogenesis of chronic rhinosinusitis.
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DOI：
10.1016/j.jaci.2022.02.016
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发表时间：
2022-05
影响因子：
14.2
通讯作者：
Bleier, Benjamin S.
中科院分区：
文献类型：
--
作者：
Kato, Atsushi;Schleimer, Robert P.;Bleier, Benjamin S.
慢性鼻窦炎（CRS）是一种异质性疾病，其特征在于上呼吸道的局部炎症，并且历史上分为两种主要表型：CRS伴鼻息肉（NP）（CRSwNP）和CRS不伴NP（CRSsNP）。CRS中的炎症主要以基于典型淋巴细胞细胞因子升高的三种内型为特征; 1型（T1）为Th 1细胞因子IFN-γ，T2为Th 2细胞因子IL-4、IL-5和IL-13，T3为Th 17细胞因子，包括IL-17。CRSsNP和CRSwNP中的炎症是高度异质性的，并且各种内源型的频率在世界各地的地理位置上不同。这一发现使建立CRS发病机制的统一认识变得复杂。鼻腔鼻窦上皮作为被动屏障，上皮屏障功能障碍是内源性细胞因子直接或间接诱导CRS的共同特征。鼻窦上皮还通过先天模式识别受体的识别参与先天免疫，并通过释放趋化因子和先天细胞因子（包括TSLP）促进和调节适应性免疫。这篇综述的目的是讨论上皮细胞对CRS发病机制的贡献，并更新有关内源性异质性和各种机制的领域，以了解CRS的发病机制。
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and is historically divided into two main phenotypes: CRS with nasal polyps (NPs) (CRSwNP) and CRS without NPs (CRSsNP). Inflammation in CRS is mainly characterized by three endotypes based on elevation of canonical lymphocyte cytokines; type 1 (T1) by Th1 cytokine IFN-γ, T2 by Th2 cutokines IL-4, IL-5 and IL-13 and T3 by Th17 cytokines including IL-17. Inflammation in both CRSsNP and CRSwNP is highly heterogeneous and the frequency of various endotypes varies geographically around the world. This finding complicates establishment of a unified understanding of the mechanisms of pathogenesis in CRS. Sinonasal epithelium acts as a passive barrier and epithelial barrier dysfunction is a common feature in CRS induced by endotype specific cytokines directly and indirectly. The sinonasal epithelium also participates in both innate immunity via recognition by innate pattern recognition receptors and promotes and regulates adaptive immunity via release of chemokines and innate cytokines including TSLP. The purpose of this review is to discuss the contribution of the epithelium to CRS pathogenesis and to update the field regarding endotypic heterogeneity and various mechanisms for understanding pathogenesis in CRS.
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影响因子：
14.2
作者：
Gevaert, Elien;Zhang, Nan;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
14.2
作者：
Gevaert, Philippe;Saenz, Rebecca;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
7.2
作者：
Fokkens, Wytske J.;Lund, Valerie J.;Zwetsloot, Casper P.
通讯作者：
Zwetsloot, Casper P.
嗜酸性粒细胞在有或没有鼻息音的慢性鼻塞炎中的生物学和功能。
DOI：
10.4168/aair.2021.13.1.8
发表时间：
2021-01
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Bochner BS;Stevens WW
通讯作者：
Stevens WW
影响因子：
24.8
作者：
Dwyer DF;Ordovas-Montanes J;Allon SJ;Buchheit KM;Vukovic M;Derakhshan T;Feng C;Lai J;Hughes TK;Nyquist SK;Giannetti MP;Berger B;Bhattacharyya N;Roditi RE;Katz HR;Nawijn MC;Berg M;van den Berge M;Laidlaw TM;Shalek AK;Barrett NA;Boyce JA
通讯作者：
Boyce JA