Biology and Function of Eosinophils in Chronic Rhinosinusitis With or Without Nasal Polyps.
Biology and Function of Eosinophils in Chronic Rhinosinusitis With or Without Nasal Polyps.
复制标题
嗜酸性粒细胞在有或没有鼻息音的慢性鼻塞炎中的生物学和功能。
DOI：
10.4168/aair.2021.13.1.8
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Stevens WW
中科院分区：
文献类型：
--
作者：
Bochner BS;Stevens WW
慢性鼻窦炎（CRS）伴或不伴鼻息肉病是一种复杂的医学疾病，其特征在于慢性先天性和适应性粘膜炎症的不同模式。CRS的治疗传统上仅限于皮质类固醇和鼻窦手术;然而，新的生物制剂最近被评估为类固醇和手术保留选择。虽然很明显CRS有不同的亚型或内型，但可能最常见的表现涉及2型炎症的特征，包括突出的组织嗜酸性粒细胞增多组分。本综述的目的是提供嗜酸性粒细胞生物学以及嗜酸性粒细胞及其介质对CRS病理生理学的潜在贡献的最新信息，主要从人类鼻窦粘膜组织、鼻分泌物和使用各种药物治疗的益处（或缺乏）的研究中得出机械结论。从这种方法得出的不可避免的结论是，嗜酸性粒细胞本身不能完全解释这种复杂疾病的潜在病理生理学。
Chronic rhinosinusitis (CRS) with or without nasal polyposis is a complex medical condition characterized by varying patterns of chronic innate and adaptive mucosal inflammation. Treatment of CRS has been traditionally limited to corticosteroids and sinus surgery; however, novel biologics have more recently been evaluated as steroid- and surgery-sparing options. While it is clear that there are different subtypes or endotypes of CRS, perhaps the most frequent presentation involves the features of type 2 inflammation, including a prominent tissue eosinophilia component. The purpose of this review is to provide an update on eosinophil biology as well as on the potential contribution of eosinophils and their mediators to the pathophysiology of CRS, drawing mechanistic conclusions mainly from studies of human sinus mucosal tissues, nasal secretions, and benefits (or lack thereof) from the use of various pharmacotherapies. The unavoidable conclusion derived from this approach is that eosinophils themselves cannot fully explain the underlying pathophysiology of this complex disorder.
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DOI：
10.1111/cea.12472
发表时间：
2015-02
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Hulse KE;Stevens WW;Tan BK;Schleimer RP
通讯作者：
Schleimer RP
影响因子：
14.2
作者：
Gevaert, Elien;Zhang, Nan;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
14.2
作者：
Gevaert, Philippe;Calus, Lien;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
120.7
作者：
Bachert, Claus;Mannent, Leda;Sutherland, E. Rand
通讯作者：
Sutherland, E. Rand
影响因子：
5.5
作者：
Abdala-Valencia H;Coden ME;Chiarella SE;Jacobsen EA;Bochner BS;Lee JJ;Berdnikovs S
通讯作者：
Berdnikovs S