Twin-screw granulation: Understanding the mechanical properties from powder to tablets
Twin-screw granulation: Understanding the mechanical properties from powder to tablets
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双螺杆造粒：了解从粉末到片剂的机械性能
DOI：
10.1016/j.powtec.2018.05.013
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发表时间：
2019
影响因子：
5.2
通讯作者：
Khorsheed B
中科院分区：
文献类型：
--
作者：
Khorsheed B
制粒是压片前常用的技术，因为它解决了粉末处理问题，并确保压片模具的均匀填充。然而，制粒可能会对粉末转化为片剂产生不利影响;即压片性。这项工作的目的是检查使用双螺杆造粒机（TSG）的连续湿法制粒对制粒材料的压片性的影响。此外，该研究还探讨了使用TSG湿法制粒后可压片性变化的机制。使用一系列机械和X射线分析技术表征了颗粒和片剂特性。发现使用TSG的湿法制粒对制粒药用辅料的可压片性有影响。所提出的工作表明，有一个屈服压力之间的相关性，塑料和弹性工作的主要粉末和制粒后的可压片性的变化百分比。该研究发现，与直接压片粉末相比，微晶纤维素（MCC）等可塑性变形材料在制粒时的可压片性显著降低（高达67%）。另一方面，脆性材料（如结晶甘露醇C160或无水磷酸氢钙）在双螺杆制粒后仍保持其可压片性。所示结果表明，微晶纤维素和甘露醇100 SD的粒度在研究范围内不影响可压片性。然而，发现增加颗粒强度会导致可压片性降低。另一方面，甘露醇C160和无水磷酸氢钙的粒度影响其压片性。
Granulation is a technique commonly used before tabletting because it solves powder handling problems and ensures uniform filling of the compression dies. However, granulation can have an adverse impact on powder transformation into a tablet; i.e. tabletability.The aim of this work is to examine the effect of continuous wet granulation using twin-screw granulator (TSG) on the tabletability of the granulated materials. Also, the study investigates the mechanisms that dictate the change in tabletability after wet granulation using TSG.Granules and tablet properties were characterised using a range of mechanical and X-ray analysis techniques. It was found that wet granulation using TSG has an impact on the tabletability of the granulated pharmaceutical excipients. The presented work suggests that there is a correlation between the yield pressure, plastic and elastic work of the primary powder and the percentage of change in tabletability after granulation. The study found that plastically deformable materials like microcrystalline cellulose (MCC) experience a significant reduction of tabletability (up to 67%) when granulated compared with the direct compression of its powder. On the other hand, brittle materials like crystalline mannitol C160 or calcium phosphate dibasic anhydrous maintain their tabletability after twin-screw granulation.The presented results show that the granule size of microcrystalline cellulose and mannitol 100 SD does not affect tabletability for the range studied. However increasing the strength of granules was found to cause reduction of the tabletability. On the other hand, the granule size of mannitol C160 and calcium phosphate dibasic anhydrous did affect its tabletability.
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