Effects of QWBZP on T-cell subsets and their cytokines in intestinal mucosa of HRV infection suckling mice.
Effects of QWBZP on T-cell subsets and their cytokines in intestinal mucosa of HRV infection suckling mice.
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QWBZP 对 HRV 感染乳鼠肠粘膜 T 细胞亚群及其细胞因子的影响。
DOI：
10.1016/j.jep.2010.06.014
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发表时间：
2010-08
影响因子：
5.4
通讯作者：
中科院分区：
文献类型：
--
作者：
七味白珠散（QWBZP）是一种传统的中药方剂，用于治疗婴幼儿腹泻，包括人轮状病毒（HRV）引起的婴幼儿腹泻。在本研究中，我们研究了茯苓多糖提取物的药理活性。材料与方法以HRV致腹泻的哺乳期小鼠为研究对象。检测肠黏膜上皮细胞CD3+、CD4+、CD8+T细胞密度及IL-2、IFN-γ、IL-4、IL-10 mRNA表达。结果芪白芍提取物可促进肠黏膜上皮细胞IL-2、IL-4、IL-10和IFN-γ mRNA的表达。同时，我们发现，与模型组相比，QWBZP组大鼠肠黏膜上皮细胞CD8+细胞密度明显降低，而CD8+细胞密度明显高于模型组。结论茯苓多糖提取物可能通过调节小肠黏膜上皮细胞t细胞亚群的密度及其细胞因子的表达而发挥抗病毒作用。
AIM OF THIS STUDYQiwei Baizhu Powder (QWBZP) is a traditional herbal prescription that has been used traditionally for the treatment of infantile diarrhea, including the infantile diarrhea caused by Human Rotavirus (HRV). In this study, we investigated the pharmacological activity of QWBZP extract.MATERIALS AND METHODSNIH suckling mice with HRV induced diarrhea were used. Density of CD3+, CD4+and CD8+T cells, mRNA expression of IL-2, IFN-γ, IL-4 and IL-10 in intestinal mucosa epithelial cells were assayed.RESULTSQWBZP extract promoted the expressions of mRNA of IL-2, IL-4, IL-10 and IFN-γ in intestinal mucosa epithelial cells. Also, we found that the density of CD8+cells in intestinal mucosa epithelial cells was significantly lower in QWBZP group than in Model group, while the density of CD8+cells was significantly higher in QWBZP group than in Model group.CONCLUSIONThese data suggest that QWBZP extract may exhibit antiviral effects through modulating the densities of T-cell subsets and the expressions of their cytokines in small intestinal mucosa epithelial cells.
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影响因子：
1.8
作者：
K. Parsons;G. Hall;J. Bridger;R. Cook
通讯作者：
K. Parsons;G. Hall;J. Bridger;R. Cook
影响因子：
5.4
作者：
Azevedo, MSP;Yuan, L;Saif, LJ
通讯作者：
Saif, LJ
影响因子：
5.4
作者：
P. Offit
通讯作者：
P. Offit
DOI：
10.1073/pnas.2636938100
发表时间：
2003-12-23
影响因子：
11.1
作者：
Sullivan, BM;Juedes, A;Glimcher, LH
通讯作者：
Glimcher, LH
影响因子：
3.1
作者：
Flach, CF;Lange, S;Holmgren, J
通讯作者：
Holmgren, J