Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics.
Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics.
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DOI：
10.1038/s41419-017-0105-5
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发表时间：
2018-02-28
影响因子：
9
通讯作者：
Wieckowski MR
中科院分区：
文献类型：
--
作者：
Janikiewicz J;Szymański J;Malinska D;Patalas-Krawczyk P;Michalska B;Duszyński J;Giorgi C;Bonora M;Dobrzyn A;Wieckowski MR
线粒体和内质网（ER）之间的紧密接触位点被称为线粒体相关膜（MAM）或线粒体-ER接触（MERC），并且在细胞生理学和病理学中起重要作用。越来越多的证据表明，MAM的分子组成和MERC数量的变化使MAM被认为是一种动态结构。它参与的过程，如脂质的生物合成和运输，钙稳态，活性氧的生产，和自噬已被实验证实。最近，MAM还在不同病理学的背景下进行了研究，包括阿尔茨海默病、帕金森病、肌萎缩性侧索硬化症、2型糖尿病和GM 1-神经节苷脂沉积症。MAM与衰老或衰老过程之间的数据联系被低估。在本综述中，我们总结了目前的基本MAM生物学，组成和行动的知识，并讨论了潜在的连接支持的想法，MAM是长寿的重要球员。
Sites of close contact between mitochondria and the endoplasmic reticulum (ER) are known as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and play an important role in both cell physiology and pathology. A growing body of evidence indicates that changes observed in the molecular composition of MAM and in the number of MERCs predisposes MAM to be considered a dynamic structure. Its involvement in processes such as lipid biosynthesis and trafficking, calcium homeostasis, reactive oxygen species production, and autophagy has been experimentally confirmed. Recently, MAM have also been studied in the context of different pathologies, including Alzheimer's disease, Parkinson’s disease, amyotrophic lateral sclerosis, type 2 diabetes mellitus and GM1-gangliosidosis. An underappreciated amount of data links MAM with aging or senescence processes. In the present review, we summarize the current knowledge of basic MAM biology, composition and action, and discuss the potential connections supporting the idea that MAM are significant players in longevity.
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影响因子：
4.3
作者：
Bonora, Massimo;Bononi, Angela;Pinton, Paolo
通讯作者：
Pinton, Paolo
影响因子：
15.9
作者：
Banerjee, Rebecca;Beal, M. Flint;Thomas, Bobby
通讯作者：
Thomas, Bobby
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1016/j.bbamcr.2010.08.007
发表时间：
2011-04
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Deas E;Wood NW;Plun-Favreau H
通讯作者：
Plun-Favreau H
影响因子：
64.5
作者：
Durham, William J.;Aracena-Parks, Paula;Hamilton, Susan L.
通讯作者：
Hamilton, Susan L.