Accelerated waning of the humoral response to COVID-19 vaccines in obesity.
Accelerated waning of the humoral response to COVID-19 vaccines in obesity.
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DOI：
10.1038/s41591-023-02343-2
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发表时间：
2023-05
期刊：
影响因子：
82.9
通讯作者：
Thaventhiran, James E. D.
中科院分区：
文献类型：
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作者：
van der Klaauw, Agatha C.;Horner, Emily;Pereyra-Gerber, Pehuen;Agrawal, Utkarsh S.;Foster, William;Spencer, Sarah;Vergese, Bensi;Smith, Miriam;Henning, Elana D.;Ramsay, Isobel A.;Smith, Jack M.;Guillaume, Stephane J.;Sharpe, Hayley M.;Hay, Iain;Thompson, Sam;Innocentin, Silvia H.;Booth, Lucy;Robertson, Chris;McCowan, Colin;Kerr, Steven;Mulroney, Thomas J.;O'Reilly, Martin P.;Gurugama, Thevinya P.;Gurugama, Lihinya A.;Rust, Maria;Ferreira, Alex;Ebrahimi, Soraya;Ceron-Gutierrez, Lourdes;Scotucci, Jacopo;Kronsteiner, Barbara J.;Dunachie, Susanna;Klenerman, Paul J.;Park, Adrian A.;Rubino, Francesco;Lamikanra, Abigail;Stark, Hannah;Kingston, Nathalie;Estcourt, Lise;Harvala, Heli;Roberts, David A.;Doffinger, Rainer J.;Linterman, Michelle;Matheson, Nicholas;Sheikh, Aziz;Farooqi, I. Sadaf;Thaventhiran, James E. D.
肥胖与严重2019冠状病毒病（COVID-19）感染和死亡的风险增加有关。COVID-19疫苗降低了严重COVID-19后果的风险;然而，其对肥胖人群的有效性尚不完全清楚。我们使用2019冠状病毒病早期大流行评估和加强监测（EAVE II）监测平台，研究了苏格兰360万人的体重指数（BMI）、住院率和死亡率之间的关系。我们发现，严重肥胖（BMI> 40 kg/m2）的接种者因COVID-19住院或死亡的可能性增加76%（调整后的率比为1.76（95%置信区间（CI），1.60 - 1.94）。我们还进行了一项前瞻性纵向研究，研究对象为28名重度肥胖患者和41名BMI正常（BMI 18.5 - 24.9 kg/m2）的对照组。我们发现，55%的严重肥胖个体在第二次接种疫苗后6个月，对真正的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）病毒的中和抗体滴度无法定量，而BMI正常的个体为12%（P = 0.0003）。此外，我们观察到，对于严重肥胖的个体，在任何给定的抗刺突和抗受体结合结构域（RBD）抗体水平下，中和能力低于BMI正常的个体。第三剂疫苗恢复了中和能力，但严重肥胖者的中和能力再次下降得更快。我们证明，在严重肥胖的个体中，COVID-19疫苗诱导的体液免疫的减弱加速。由于肥胖与突破性感染的住院率和死亡率增加有关，我们的研究结果对疫苗优先政策具有影响。流行病学分析加上免疫表型表明，与BMI在正常范围内的个体相比，COVID-19疫苗诱导的体液免疫在严重肥胖的个体中衰减得更快。
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people with obesity is incompletely understood. We studied the relationship among body mass index (BMI), hospitalization and mortality due to COVID-19 among 3.6 million people in Scotland using the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) surveillance platform. We found that vaccinated individuals with severe obesity (BMI > 40 kg/m2) were 76% more likely to experience hospitalization or death from COVID-19 (adjusted rate ratio of 1.76 (95% confidence interval (CI), 1.60–1.94). We also conducted a prospective longitudinal study of a cohort of 28 individuals with severe obesity compared to 41 control individuals with normal BMI (BMI 18.5–24.9 kg/m2). We found that 55% of individuals with severe obesity had unquantifiable titers of neutralizing antibody against authentic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus compared to 12% of individuals with normal BMI (P = 0.0003) 6 months after their second vaccine dose. Furthermore, we observed that, for individuals with severe obesity, at any given anti-spike and anti-receptor-binding domain (RBD) antibody level, neutralizing capacity was lower than that of individuals with a normal BMI. Neutralizing capacity was restored by a third dose of vaccine but again declined more rapidly in people with severe obesity. We demonstrate that waning of COVID-19 vaccine-induced humoral immunity is accelerated in individuals with severe obesity. As obesity is associated with increased hospitalization and mortality from breakthrough infections, our findings have implications for vaccine prioritization policies. Epidemiological analyses coupled with immunological phenotyping suggest that humoral immunity induced by COVID-19 vaccines wanes more rapidly in individuals with severe obesity compared to individuals with a BMI within the normal range.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
2.9
作者：
Harvala, Heli;Dung Nguyen;Simmonds, Peter;Lamikanra, Abigail A.;Tsang, Hoi Pat;Otter, Ashley;Maes, Piet;Webster, Mhairi;Clarkson, Adam;Kaloyirou, Fotini;Hopkins, Valerie;Laidlaw, Stephen M.;Carroll, Miles;Mora, Ana;Griffiths, Alexandra;MacLennan, Sheila;Estcourt, Lise;Roberts, David J.
通讯作者：
Roberts, David J.
老年人的记忆B细胞对流感疫苗接种的反应受损。
影响因子：
8.8
作者：
通讯作者：
--
DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G
影响因子：
3.5
作者：
Eliakim, A;Swindt, C;Cooper, DM
通讯作者：
Cooper, DM