Advances in Mesenchymal Stem Cell-Derived Exosomes as Drug Delivery Vehicles.
Advances in Mesenchymal Stem Cell-Derived Exosomes as Drug Delivery Vehicles.
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间充质干细胞来源的外泌体作为药物输送载体的进展
DOI：
10.3389/fbioe.2021.797359
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发表时间：
2021
影响因子：
5.7
通讯作者：
Tang Z
中科院分区：
文献类型：
--
作者：
Rao D;Huang D;Sang C;Zhong T;Zhang Z;Tang Z
外泌体是细胞产生的具有双膜结构的微小囊泡。它们的直径范围为40至150 nm，可能含有各种生物分子，包括蛋白质和核酸。外泌体具有低毒性、低免疫原性和包封多种物质的能力，使其成为有吸引力的药物递送载体。MSC分泌大量的外泌体，因此作为外泌体的极好来源。MSC衍生的外泌体具有与MSC相当的再生和组织修复功能，并且可以规避与MSC移植相关的免疫排斥和感染的风险，这表明它们可能是MSC生物学功能的可行替代品。本文综述了外泌体的给药方法和优点，以及MSC外泌体作为药物载体的研究进展。介绍了外泌体作为药物载体的挑战和前景。
Exosomes are tiny vesicles with a double membrane structure that cells produce. They range in diameter from 40 to 150 nm and may contain a variety of biomolecules including proteins and nucleic acids. Exosomes have low toxicity, low immunogenicity, and the ability to encapsulate a wide variety of substances, making them attractive drug delivery vehicles. MSCs secrete large amounts of exosomes and hence serve as an excellent source of exosomes. MSCs-derived exosomes have regenerative and tissue repair functions comparable to MSCs and can circumvent the risks of immune rejection and infection associated with MSC transplantation, indicating that they may be a viable alternative to MSCs’ biological functions. In this review, we summarized the drug delivery methods and advantages of exosomes, as well as the advancement of MSC exosomes as drug carriers. The challenges and prospects of using exosomes as drug delivery vectors are presented.
影响因子：
3.3
作者：
Jackson, Wesley M.;Alexander, Peter G.;Bulken-Hoover, Jamie D.;Vogler, Jared A.;Ji, Youngmi;McKay, Patricia;Nesti, Leon J.;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.