Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity.
Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity.
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DOI：
10.1371/journal.pone.0075560
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Umemura S
中科院分区：
文献类型：
--
作者：
Azushima K;Tamura K;Wakui H;Maeda A;Ohsawa M;Uneda K;Kobayashi R;Kanaoka T;Dejima T;Fujikawa T;Yamashita A;Toya Y;Umemura S
越来越多的证据表明，代谢功能障碍与内脏型肥胖是一个主要的医学问题，与高血压、2型糖尿病（T2DM）和血脂异常的发展有关，并最终导致严重的心血管和肾脏疾病。因此，有效的抗肥胖治疗与代谢谱的改善对于治疗内脏性肥胖的代谢功能障碍是重要的。bofu - tsus -shosan （BOF）是一种东方草药，在日本临床上可用于治疗肥胖。虽然BOF是改善肥胖代谢功能障碍的一种新的治疗策略，但其有益作用的机制尚未完全阐明。在此，我们研究了BOF对人类代谢紊乱伴肥胖模型KKAy小鼠的治疗作用机制。慢性治疗的KKAy小鼠BOF持续减少食物摄入量，体重增加，低密度脂蛋白胆固醇和收缩压。此外，BOF处理降低了白色脂肪组织（WAT）的组织重量和细胞大小，同时增加了WAT中脂联素和过氧化物酶体增殖物激活受体基因的表达以及循环脂联素水平。此外，脱偶联蛋白1（一种产热因子）在棕色脂肪组织中的基因表达和直肠温度均被BOF升高。有趣的是，单次给予BOF后，血浆酰化胃饥饿素（一种活性的促氧激素）和短期食物摄入量显著减少。这些结果表明，BOF至少部分地通过对脂肪组织功能的有益作用和通过抑制胃饥饿素系统的食欲抑制作用来发挥组合有利的代谢调节作用，包括降压作用。
Accumulating evidence indicates that metabolic dysfunction with visceral obesity is a major medical problem associated with the development of hypertension, type 2 diabetes (T2DM) and dyslipidemia, and ultimately severe cardiovascular and renal disease. Therefore, an effective anti-obesity treatment with a concomitant improvement in metabolic profile is important for the treatment of metabolic dysfunction with visceral obesity. Bofu-tsu-shosan (BOF) is one of oriental herbal medicine and is clinically available to treat obesity in Japan. Although BOF is a candidate as a novel therapeutic strategy to improve metabolic dysfunction with obesity, the mechanism of its beneficial effect is not fully elucidated. Here, we investigated mechanism of therapeutic effects of BOF on KKAy mice, a model of human metabolic disorders with obesity. Chronic treatment of KKAy mice with BOF persistently decreased food intake, body weight gain, low-density lipoprotein cholesterol and systolic blood pressure. In addition, both tissue weight and cell size of white adipose tissue (WAT) were decreased, with concomitant increases in the expression of adiponectin and peroxisome proliferator-activated receptors genes in WAT as well as the circulating adiponectin level by BOF treatment. Furthermore, gene expression of uncoupling protein-1, a thermogenesis factor, in brown adipose tissue and rectal temperature were both elevated by BOF. Intriguingly, plasma acylated-ghrelin, an active form of orexigenic hormone, and short-term food intake were significantly decreased by single bolus administration of BOF. These results indicate that BOF exerts a combinatorial favorable metabolic modulation including antihypertensive effect, at least partially, via its beneficial effect on adipose tissue function and its appetite-inhibitory property through suppression on the ghrelin system.
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影响因子：
8.9
作者：
Dorresteijn, J. A. N.;Visseren, F. L. J.;Spiering, W.
通讯作者：
Spiering, W.
DOI：
10.1001/jama.2010.1505
发表时间：
2010-10-27
期刊：
JAMA
影响因子：
--
作者：
Goodpaster BH;Delany JP;Otto AD;Kuller L;Vockley J;South-Paul JE;Thomas SB;Brown J;McTigue K;Hames KC;Lang W;Jakicic JM
通讯作者：
Jakicic JM
影响因子：
29.4
作者：
Date, Y;Murakami, N;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
--
作者：
Horvath, Karl;Jeitler, Klaus;Siebenhofer, Andrea
通讯作者：
Siebenhofer, Andrea
影响因子：
8.3
作者：
Ohashi, Koji;Kihara, Shinji;Shimomura, Iichiro
通讯作者：
Shimomura, Iichiro