Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms.
Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms.
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DOI：
10.1124/mol.119.119107
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发表时间：
2020-10
影响因子：
3.6
通讯作者：
Blendy JA
中科院分区：
文献类型：
--
作者：
Eacret D;Veasey SC;Blendy JA
数百万美国人患有阿片类药物使用障碍，每天有100多人死于阿片类药物过量。阿片类药物的使用往往发展成滥用和戒断的恶性循环，导致非常高的复发率。虽然阿片类药物戒断的生理和心理症状有充分的文献记载，但慢性阿片类药物暴露和戒断引起的睡眠障碍却鲜为人知。这些物质会对睡眠造成严重的长期影响。然而，睡眠不足可能会影响阿片类药物的使用，这表明睡眠不足和阿片类药物使用之间存在双向前馈相互作用。阿片类药物如何影响睡眠以及睡眠中断如何影响阿片类药物使用的神经生物学尚不清楚。在这里，我们将总结已知的阿片类药物对人类和动物模型脑电图睡眠的影响。然后，我们讨论了介导觉醒和觉醒的奖励相关大脑区域之间的神经生物学接口，以及阿片类药物在睡眠相关大脑区域和神经递质系统中的作用。最后，我们总结了阿片类药物暴露和睡眠的已知机制。对这些研究的批判性回顾，以及评估戒断期间操纵睡眠影响的研究建议，将进一步加深我们对睡眠和阿片类药物使用之间周期性反馈的理解。我们回顾了阿片类药物与睡眠相关机制的最新研究。阿片类药物影响睡眠，睡眠影响阿片类药物的使用；然而，这种关系背后的生物学原理尚不清楚。这篇综述汇编了这一领域的最新研究，填补了这一知识空白。
Millions of Americans suffer from opiate use disorder, and over 100 die every day from opioid overdoses. Opioid use often progresses into a vicious cycle of abuse and withdrawal, resulting in very high rates of relapse. Although the physical and psychologic symptoms of opiate withdrawal are well-documented, sleep disturbances caused by chronic opioid exposure and withdrawal are less well-understood. These substances can significantly disrupt sleep acutely and in the long term. Yet poor sleep may influence opiate use, suggesting a bidirectional feed-forward interaction between poor sleep and opioid use. The neurobiology of how opioids affect sleep and how disrupted sleep affects opioid use is not well-understood. Here, we will summarize what is known about the effects of opioids on electroencephalographic sleep in humans and in animal models. We then discuss the neurobiology interface between reward-related brain regions that mediate arousal and wakefulness as well as the effect of opioids in sleep-related brain regions and neurotransmitter systems. Finally, we summarize what is known of the mechanisms underlying opioid exposure and sleep. A critical review of such studies, as well as recommendations of studies that evaluate the impact of manipulating sleep during withdrawal, will further our understanding of the cyclical feedback between sleep and opioid use. We review recent studies on the mechanisms linking opioids and sleep. Opioids affect sleep, and sleep affects opioid use; however, the biology underlying this relationship is not understood. This review compiles recent studies in this area that fill this gap in knowledge.
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影响因子：
82.9
作者：
Alexandre C;Latremoliere A;Ferreira A;Miracca G;Yamamoto M;Scammell TE;Woolf CJ
通讯作者：
Woolf CJ
影响因子：
25
作者：
Eban-Rothschild A;Rothschild G;Giardino WJ;Jones JR;de Lecea L
通讯作者：
de Lecea L
影响因子：
8.8
作者：
Gauthier, Elizabeth A.;Guzick, Sarah E.;Lydic, Ralph
通讯作者：
Lydic, Ralph
影响因子：
11
作者：
Ge, Feifei;Mu, Ping;Huang, Yanhua H.
通讯作者：
Huang, Yanhua H.
影响因子：
64.5
作者：
Chemelli, RM;Willie, JT;Yanagisawa, M
通讯作者：
Yanagisawa, M