Decreased alertness due to sleep loss increases pain sensitivity in mice.
Decreased alertness due to sleep loss increases pain sensitivity in mice.
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DOI：
10.1038/nm.4329
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发表时间：
2017-06
期刊：
影响因子：
82.9
通讯作者：
Woolf CJ
中科院分区：
文献类型：
--
作者：
Alexandre C;Latremoliere A;Ferreira A;Miracca G;Yamamoto M;Scammell TE;Woolf CJ
长时间的白天和夜间活动是日益严重的睡眠不足流行病的主要原因，失眠等睡眠障碍的高发也是如此。长期睡眠不足对健康的影响仍不确定。健康受试者的睡眠质量和持续时间可以预测第二天疼痛的存在，这表明睡眠障碍本身可能会加重疼痛，而人类睡眠剥夺的实验支持了这一说法。我们证明，在健康小鼠中，睡眠不足而不是睡眠碎片会增加对有害刺激（称为“疼痛”）的敏感性，但不会产生一般的感觉超反应。每天适度的反复睡眠不足会导致睡眠债务的逐渐积累，也会导致疼痛反应的夸大，这两种情况在恢复正常睡眠后都会得到缓解。咖啡因和莫达非尼是两种促进清醒的药物，在休息的小鼠中没有镇痛作用，但在睡眠不足的小鼠中，它们的疼痛敏感性立即恢复正常，而不会影响睡眠债务。唤醒促进剂引起的轻度睡眠缺失引起的疼痛的可逆性揭示了警觉性在设置疼痛敏感性方面的不可预料的作用。临床上，睡眠不足或睡眠质量差可能会加重疼痛，这种加重的疼痛可能不是通过镇痛药来减轻，而是通过提高警觉性或提供更好的睡眠来减轻，因为镇痛药的效果会降低。
Extended daytime and nighttime activities are major contributors to the growing sleep deficiency epidemic, as is the high prevalence of sleep disorders like insomnia. The consequences of chronic insufficient sleep for health remain uncertain. Sleep quality and duration predict presence of pain the next day in healthy subjects, suggesting that sleep disturbances alone may worsen pain, and experimental sleep deprivation in humans supports this claim. We demonstrate that sleep loss, but not sleep fragmentation, in healthy mice increases sensitivity to noxious stimuli (referred to as ‘pain’) without general sensory hyper-responsiveness. Moderate daily repeated sleep loss leads to a progressive accumulation of sleep debt and also to exaggerated pain responses, both of which are rescued after restoration of normal sleep. Caffeine and modafinil, two wake-promoting agents that have no analgesic activity in rested mice, immediately normalize pain sensitivity in sleep-deprived animals, without affecting sleep debt. The reversibility of mild sleep-loss-induced pain by wake-promoting agents reveals an unsuspected role for alertness in setting pain sensitivity. Clinically, insufficient or poor-quality sleep may worsen pain and this enhanced pain may be reduced not by analgesics, whose effectiveness is reduced, but by increasing alertness or providing better sleep.
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影响因子：
3.7
作者：
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DOI：
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发表时间：
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期刊：
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