Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component
Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component
复制标题
血液透析相关淀粉样变性的 123I 血清淀粉样蛋白 P 成分成像
DOI：
10.1016/0140-6736(91)90478-8
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
D.O Oliver
中科院分区：
文献类型：
--
作者：
S.R Nelson;P. N. Hawkins;S. Richardson;M. Pepys;J. Lavender;D. Sethi;P. Gower;C.W Pugh;C. G. Winearls;D.O Oliver
长期血液透析常伴有淀粉样蛋白沉积，其中原纤维由β2-微球蛋白组成。与透析相关的淀粉样蛋白疾病引起广泛的发病率，并在某些情况下与死亡有关。所有淀粉样蛋白沉积都含有淀粉样蛋白P成分，它来源于正常循环蛋白，血清淀粉样蛋白P成分（SAP）。我们对38例接受长期血液透析的终末期肾衰竭患者注射123i标记SAP后的显像评估淀粉样变性的分布。组织学检查证实淀粉样蛋白沉积的所有部位均有示踪剂的局灶性定位。12例患者可见脾摄取，提示脾淀粉样变性，但没有其他内脏受累的证据。6名透析时间在1.5年以下的对照组未发现示踪剂的定位，3名组织学证实淀粉样变性且123i - sap图像阳性的长期透析患者也未发现123i标记的人血清白蛋白的摄取。5例8- 2.4年前移植的患者，尽管既往有透析性关节病(5)和组织学证实的淀粉样变(4)，但扫描结果均为阴性。123i - sap显像作为一种非侵入性方法，可能有助于诊断和监测透析相关淀粉样变。
Long-term haemodialysis is frequently complicated by amyloid deposition in which the fibrils consist of β2-microglobulin. Dialysis-related amyloid disease causes extensive morbidity and has been associated with deaths in some cases. All amyloid deposits contain amyloid P component that is derived from the normal circulating protein, serum amyloid P component (SAP). We have used scintigraphic imaging after injection of123I-labelled SAP to assess the distribution of amyloidosis in 38 patients receiving long-term haemodialysis for end-stage renal failure. There was focal localisation of tracer at all sites where histological examination confirmed amyloid deposition. Splenic uptake was seen in 12 patients, indicating splenic amyloidosis, but there was no evidence of other visceral involvement. 6 control subjects who had been dialysed for under 1·5 years showed no localisation of tracer, nor was there any uptake of123I-labelled human serum albumin in 3 long-term dialysis patients with histologically confirmed amyloidosis and positive123I-SAP images. Negative scans were also obtained in 5 patients who had been transplanted 0·8-2·4 years previously, despite past evidence of dialysis arthropathy (5) and histologically proven amyloidosis (4).123I-SAP scintigraphy may be helpful as a non-invasive method for both the diagnosis and monitoring of dialysis-associated amyloidosis.
来自原发性特发性淀粉样变性患者的人体组织淀粉样蛋白 P 成分的一级结构。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Prelli,F;Pras,M;Frangione,B
通讯作者：
Frangione,B
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Mantzouranis,EC;Dowton,SB;Whitehead,AS;Edge,MD;Bruns,GA;Colten,HR
通讯作者：
Colten,HR
DOI：
10.1016/0006-291x(85)91948-5
发表时间：
1985-01-01
影响因子：
3.1
作者：
GEJYO, F;YAMADA, T;SCHMID, K
通讯作者：
SCHMID, K