Reconsolidation of a well-learned instrumental memory.
Reconsolidation of a well-learned instrumental memory.
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DOI：
10.1101/lm.035543.114
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Lee JL
中科院分区：
文献类型：
--
作者：
Exton-McGuinness MT;Patton RC;Sacco LB;Lee JL
一旦巩固，记忆是动态的实体，经历不稳定的阶段，以便通过重新巩固的过程用新信息更新。再固结现象已经在各种各样的实验范例中得到证实。然而，支持工具性行为的记忆目前并不被认为会重新巩固。我们发现，在大鼠中学习良好的杠杆按压确实经历了再巩固，当在转换为可变但非固定的比例方案之前全身给予非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂（+）-5-甲基-10，11-二氢-SH-二苯并[a，d]环庚烯-5，10-亚胺马来酸盐（MK-801）时，可以破坏这种再巩固。再巩固的中断导致长期压杆性能的降低，并降低了行为的敏感性，以应变变化。进一步的研究表明，表达的再巩固损伤不受结果值，这意味着在刺激-反应（S-R）过程中的赤字。破坏良好学习的工具性行为的表现的能力对于开发基于再巩固的临床治疗涉及强迫性寻求行为的条件具有潜在的重要性。
Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not believed to reconsolidate. We show that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) when administered prior to a switch to a variable, but not fixed, ratio schedule. Disruption of reconsolidation resulted in a reduction in long-term lever pressing performance and diminished the sensitivity of behavior to contingency change. Further investigation demonstrated that expression of the reconsolidation impairment was not affected by outcome value, implying a deficit in a stimulus–response (S–R) process. The ability to disrupt the performance of well-learned instrumental behaviors is potentially of great importance in the development of reconsolidation-based clinical treatments for conditions that involve compulsive seeking behaviors.
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DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
9.2
作者：
Diaz-Mataix, Lorenzo;Ruiz Martinez, Raquel Chacon;Schafe, Glenn E.;LeDoux, Joseph E.;Doyere, Valerie
通讯作者：
Doyere, Valerie
DOI：
10.3758/bf03199935
发表时间：
1995-05-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
DICKINSON, A;BALLEINE, B;BOAKES, RA
通讯作者：
BOAKES, RA
DOI：
10.1196/annals.1390.006
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
Balleine, Bernard W.;Ostlund, Sean B.
通讯作者：
Ostlund, Sean B.
DOI：
10.1037/0097-7403.30.2.104
发表时间：
2004-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Holland, PC
通讯作者：
Holland, PC