Cold sintering of bioglass and bioglass/polymer composites

Cold sintering of bioglass and bioglass/polymer composites
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生物玻璃和生物玻璃/聚合物复合材料的冷烧结

DOI:
10.1111/jace.19022
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发表时间:
2023
影响因子:
3.9
通讯作者:
Andrews J
Andrews J
中科院分区:
材料科学2区
文献类型:
--
作者:
Andrews J

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生物活性玻璃广泛用于骨组织再生和辅助骨科植入物的粘合。用生物活性聚合物形成生物玻璃复合材料可以定制机械性能和生物响应。尽管存在多种制造生物玻璃-聚合物复合材料的方法,但它们需要聚合物的溶解、受控的相分离,并且生物玻璃的上限似乎为~30vol.%。冷烧结是一种陶瓷和玻璃致密化的新技术,它利用液相和压力在降低的温度下生产部件。我们演示了通过火焰喷涂热解生产的 Bioglass 45S5 粉末的冷烧结(100°C)以及 Bioglass 45S5-聚合物复合材料的制造。体外反应评估表明复合材料不具有细胞毒性。对玻璃粉末、原样、润湿和烧结样品中硅和磷形态的固态31P和29Si MAS NMR研究表明,与生物玻璃植入体内时预期的反应相似,这与拉曼光谱数据一起深入了解了冷烧结致密化机制。
Bioactive glasses are widely utilized to regenerate bone tissue and aid bonding of orthopedic implants. Forming composites of bioglass with bioactive polymers allow the mechanical properties and biological response to be tailored. Although several methods for creating bioglass–polymer composites exist, they require dissolution of the polymer, controlled phase separation, and appear to have an upper limit of ∼30 vol.% bioglass. Cold sintering is a novel technique for the densification of ceramics and glasses which utilizes a liquid phase and pressure to allow the production of components at reduced temperatures. We demonstrate that cold sintering (100°C) of Bioglass 45S5 powder produced via flame spray pyrolysis and the fabrication of Bioglass 45S5–polymer composites. Assessment of the in vitro response revealed that composites were not cytotoxic. Solid‐state31P and29Si MAS NMR studies of the silicon and phosphorus speciation in the glass powder, as‐received, wetted, and sintered samples show similarities to reactions expected when bioglass is implanted in the body which along with Raman spectroscopy data gave insight into the cold sintering densification mechanism.
使用玻璃涂层技术在氧化锆上涂覆磷灰石。
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羟基磷灰石的偏振拉曼散射和低频红外研究
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