Structure and function of the skeletal muscle extracellular matrix.

Structure and function of the skeletal muscle extracellular matrix.
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DOI:
10.1002/mus.22094
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发表时间:
2011-09
期刊:
影响因子:
3.4
通讯作者:
Lieber, Richard L.
Lieber, Richard L.
中科院分区:
医学3区
文献类型:
--
作者:
Gillies, Allison R.;Lieber, Richard L.

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骨骼肌细胞外基质(ECM)在肌纤维力的传递、维持和修复中发挥着重要作用。在受伤和患病状态下,ECM 都会发生显着的适应,这种特性会出现临床表现并改变肌肉功能。在这里,我们回顾了骨骼肌 ECM 的结构、组成和机械特性,描述了有助于维持 ECM 的细胞,最后概述了病理学发生的变化。 ECM 结构的新扫描电子显微照片也提出了有关 ECM 结构-功能关系的假设。 ECM 的详细结构-功能关系尚未确定,因此,我们提出了未来研究的领域。
The skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property thathas clinical manifestations and alters muscle function. Here, we review the structure, composition, and mechanical properties of skeletal muscle ECM, describe the cells that contribute to the maintenance of the ECM and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure-function relationships. Detailed structure-function relationships of the ECM have yet to be defined and, as a result, we propose areas for future studies.
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