Increased levels of endothelin-1 in bronchoalveolar lavage fluid of patients with lung allografts.
Increased levels of endothelin-1 in bronchoalveolar lavage fluid of patients with lung allografts.
复制标题
同种异体肺移植患者的支气管肺泡灌洗液中内皮素-1 水平升高。
DOI：
10.1016/s0022-5223(96)70423-3
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
F. Nilsson
中科院分区：
文献类型：
--
作者：
H. Scherstén;T. Hedner;C. McGregor;V. Miller;G. Mårtensson;G. Riise;F. Nilsson
本研究的目的是测定肺和心肺同种异体移植患者支气管肺泡灌洗液和血浆中内皮素-1的水平。目的是基于假设内皮素-1水平在肺移植患者的支气管肺泡灌洗液中升高。接受心肺（n = 8）、单肺（n = 10）或双肺（n = 5）移植的患者（n = 23）被纳入研究。在单肺同种异体移植患者中，分析了移植和未移植原生肺支气管肺泡灌洗液中的内皮素-1水平。我们还分析了12例未接受移植的患者支气管肺泡灌洗液中内皮素-1的水平。经支气管活检和支气管肺泡灌洗在移植后2至104周期间进行常规或临床指征64次。用放射免疫法测定大鼠支气管肺泡灌洗液和血浆中内皮素-1的水平。所有患者支气管肺泡灌洗液中均检测到免疫反应性内皮素-1。移植肺支气管肺泡灌洗液中内皮素-1浓度（2.94±0.30 pg/ml, n = 64）显著高于未移植肺支气管肺泡灌洗液（0.86±0.20 pg/ml, n = 12, p < 0.01）。肺气肿单肺移植患者，移植肺支气管肺泡灌洗液内皮素-1水平明显高于原生肺（5.61±1.9 vs 0.39±0.05 pg/ml, p < 0.05）。支气管肺泡灌洗液中内皮素-1的浓度与排斥程度、感染或移植后时间无关。血浆内皮素-1水平在肺排斥反应中没有变化。这些结果表明内皮素-1在移植肺的支气管中释放。这种释放与排斥或感染无关。由于其强大的有丝分裂特性，内皮素-1可能对移植后并发症如闭塞性细支气管炎的发生有潜在的影响。[j]中华胸心外科1996；11:53- 58。
The aim of the present study was to determine levels of endothelin-1 in bronchoalveolar lavage fluid and in plasma in patients with lung and heart-lung allografts. The aim was based on the hypothesis that levels of endothelin-1 are elevated in the bronchoalveolar lavage fluid of patients with lung allografts. Patients ( n = 23) undergoing heart-lung ( n = 8), single-lung ( n = 10), or bilateral lung ( n = 5) transplantation were included in the study. In patients with single-lung allografts, endothelin-1 levels were analyzed in bronchoalveolar lavage fluid from both the transplanted and the nontransplanted, native lung. The level of endothelin-1 was also analyzed in bronchoalveolar lavage fluid from 12 patients who did not undergo transplantation. Transbronchial biopsies and bronchoalveolar lavage were done routinely or when clinically indicated on 64 different occasions, between 2 and 104 weeks after transplantation. The level of endothelin-1 was measured in bronchoalveolar lavage fluid and plasma by radioimmunoassay. Immunoreactive endothelin-1 was detectable in bronchoalveolar lavage fluid from all patients. The concentration of endothelin-1 in bronchoalveolar lavage fluid from transplanted lungs (2.94 ± 0.30 pg/ml, n = 64) was significantly higher compared with that in bronchoalveolar lavage fluid from patients without allografts (0.86 ± 0.20 pg/ml, n = 12, p < 0.01). In patients who received single-lung transplantation because of emphysema, the level of endothelin-1 in bronchoalveolar lavage fluid from the transplanted lung was significantly greater than that from the native lung (5.61 ± 1.9 versus 0.39 ± 0.05 pg/ml, p < 0.05). Concentrations of endothelin-1 in bronchoalveolar lavage fluid did not correlate with grade of rejection, infection, or time after transplant. Plasma levels of endothelin-1 were unchanged with pulmonary rejection. These results indicate that endothelin-1 is released into bronchi of transplanted human lungs. The release is not associated with rejection or infection. Because of its potent mitogenic properties, endothelin-1 may have a potential impact in the development of posttransplant complications such as bronchiolitis obliterans. (J THORAC CARDIOVASC SURG 1996;111:253-8)
内皮素异肽对 fos 和 jun 基因表达以及 AP-1 顺式元件活性的差异调节。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Simonson,MS;Jones,JM;Dunn,MJ
通讯作者：
Dunn,MJ
DOI：
10.1161/01.hyp.15.2_suppl.i5
发表时间：
1990
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Simonson,MS;Dunn,MJ
通讯作者：
Dunn,MJ
Endothelin-1 促进气道平滑肌细胞有丝分裂。
DOI：
10.1165/ajrcmb.10.3.7509612
发表时间：
1994
影响因子：
6.4
作者：
Glassberg,MK;Ergul,A;Wanner,A;Puett,D
通讯作者：
Puett,D