Neutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)-octadecylamine conjugate for lung cancer treatment.
Neutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)-octadecylamine conjugate for lung cancer treatment.
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DOI：
10.1080/10717544.2018.1474973
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发表时间：
2018-11
期刊：
影响因子：
6
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Luo X;Hu L;Zheng H;Liu M;Liu X;Li C;Qiu Q;Zhao Z;Cheng X;Lai C;Su Y;Deng Y;Song Y
聚唾液酸（PSA）是一种天然的亲水可生物降解的非免疫原性生物聚合物，其单体受体在外周血中性粒细胞（pbn）上表达，在肿瘤的进展和侵袭中起重要作用。合成了一种聚唾液酸-十八胺缀合物（PSA-ODA），并将其锚定在吡酮脂质体（px - psl）表面，以提高其抗癌效果。采用pH梯度远程负载法制备脂质体，并对其粒径、zeta电位包封效率、体外释放度和体外细胞毒性进行了评价。同时，体外和体内细胞摄取研究证实，psa修饰的脂质体增强了脂质体在pbn中的积累。一项体内研究表明，Pix- psl的抗肿瘤活性优于其他Pix制剂，这可能是由于Pix- psl有效靶向PBNs，之后血液循环中含有Pix- psl的PBN （Pix- psl /PBNs）被肿瘤微环境招募。这些发现表明，psa修饰的Pix脂质体可能为肿瘤的根除提供了一种中性粒细胞介导的药物传递系统（DDS），这代表了一种有希望的肿瘤靶向化疗治疗方法。
Poly(sialic acid) (PSA) is a natural hydrophilic biodegradable and non-immunogenic biopolymer, receptors for its monomer are expressed on peripheral blood neutrophils (PBNs), which plays important roles in the progression and invasion of tumors. A poly(sialic acid)–octadecylamine conjugate (PSA–ODA) was synthesized and then anchor it on the surface of liposomal pixantrone (Pix-PSL), to achieve an improved anticancer effect. The liposomes were prepared using a remote loading method via a pH gradient, and then assessed for particle size, zeta potential encapsulation efficiency, in vitro release, and in vitro cytotoxicity. Simultaneously, in vitro and in vivo cellular uptake studies confirmed that PSA-decorated liposomes provided an enhanced accumulation of liposomes in PBNs. An in vivo study presented that the anti-tumor activity of Pix-PSL was superior to that of other Pix formulations, probably due to the efficient targeting of PBNs by Pix-PSL, after which PBN containing Pix-PSL (Pix-PSL/PBNs) in the blood circulation are recruited by the tumor microenvironment. These findings suggest that PSA-decorated liposomal Pix may provide a neutrophil-mediated drug delivery system (DDS) for the eradication of tumors, which represents a promising approach for the tumor targeting of chemotherapeutic treatments.
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影响因子：
11.2
作者：
Benevides L;da Fonseca DM;Donate PB;Tiezzi DG;De Carvalho DD;de Andrade JM;Martins GA;Silva JS
通讯作者：
Silva JS
影响因子：
6
作者：
Bekes, Erin M.;Schweighofer, Bernhard;Deryugina, Elena I.
通讯作者：
Deryugina, Elena I.
影响因子：
12.7
作者：
Fossati, G;Ricevuti, G;Rossi, ML
通讯作者：
Rossi, ML
DOI：
10.1111/j.1538-7836.2011.04544.x
发表时间：
2012-01
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Brill A;Fuchs TA;Savchenko AS;Thomas GM;Martinod K;De Meyer SF;Bhandari AA;Wagner DD
通讯作者：
Wagner DD
DOI：
10.1126/science.aal5081
发表时间：
2017-12-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Engblom C;Pfirschke C;Zilionis R;Da Silva Martins J;Bos SA;Courties G;Rickelt S;Severe N;Baryawno N;Faget J;Savova V;Zemmour D;Kline J;Siwicki M;Garris C;Pucci F;Liao HW;Lin YJ;Newton A;Yaghi OK;Iwamoto Y;Tricot B;Wojtkiewicz GR;Nahrendorf M;Cortez-Retamozo V;Meylan E;Hynes RO;Demay M;Klein A;Bredella MA;Scadden DT;Weissleder R;Pittet MJ
通讯作者：
Pittet MJ