It's all relative: Regression analysis with compositional predictors.
It's all relative: Regression analysis with compositional predictors.
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DOI:
10.1111/biom.13703
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发表时间:
2023-06
期刊:
影响因子:
1.9
通讯作者:
Chen, Kun
中科院分区:
文献类型:
--
作者:
Li, Gen;Li, Yan;Chen, Kun
Compositional data reside in a simplex and measure fractions or proportions of parts to a whole. Most existing regression methods for such data rely on log-ratio transformations that are inadequate or inappropriate in modeling high-dimensional data with excessive zeros and hierarchical structures. Moreover, such models usually lack a straightforward interpretation due to the interrelation between parts of a composition. We develop a novel relative-shift regression framework that directly uses proportions as predictors. The new framework provides a paradigm shift for regression analysis with compositional predictors and offers a superior interpretation of how shifting concentration between parts affects the response. New equi-sparsity and tree-guided regularization methods and an efficient smoothing proximal gradient algorithm are developed to facilitate feature aggregation and dimension reduction in regression. A unified finite-sample prediction error bound is derived for the proposed regularized estimators. We demonstrate the efficacy of the proposed methods in extensive simulation studies and a real gut microbiome study. Guided by the taxonomy of the microbiome data, the framework identifies important taxa at different taxonomic levels associated with the neurodevelopment of preterm infants.
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DOI:
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发表时间:
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期刊:
The annals of applied statistics
影响因子:
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影响因子:
2.5
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DOI:
10.1214/17-aoas1102
发表时间:
2018-03
期刊:
The annals of applied statistics
影响因子:
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通讯作者:
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