Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants.
Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants.
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DOI：
10.1016/j.xplc.2021.100267
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发表时间：
2022-01-10
影响因子：
10.5
通讯作者：
Calonje M
中科院分区：
文献类型：
--
作者：
Baile F;Gómez-Zambrano Á;Calonje M
进化保守的Polycomb Group（PcG）抑制系统包括两个中心蛋白复合物，PcG抑制复合物1（PRC1）和PRC2。这些复合物通过在染色质上掺入组蛋白修饰，在真核生物的正常发育中具有重要作用。近年来，已经作出了重大努力，以表征这些复合物在不同的王国，尽管有显着的功能和机制的保护，一些关键的分子原理已经分歧。本文就植物PcG复合物的功能进行综述。我们比较了动物和植物之间的PcG复合物的组成，突出最近发现的植物PcG辅助蛋白的作用，并讨论了新发现的已知PcG合作伙伴的作用。我们还研究了实现抑制的机制以及这些复合物如何被招募到靶基因。最后，我们考虑了一些植物PcG蛋白在介导本地和远程染色质相互作用，从而塑造染色质3D架构的可能作用。目前的图片Polycomb组阻遏系统如何在多个层次上调节植物基因表达的检查和讨论在这篇评论。
The evolutionary conserved Polycomb Group (PcG) repressive system comprises two central protein complexes, PcG repressive complex 1 (PRC1) and PRC2. These complexes, through the incorporation of histone modifications on chromatin, have an essential role in the normal development of eukaryotes. In recent years, a significant effort has been made to characterize these complexes in the different kingdoms, and despite there being remarkable functional and mechanistic conservation, some key molecular principles have diverged. In this review, we discuss current views on the function of plant PcG complexes. We compare the composition of PcG complexes between animals and plants, highlight the role of recently identified plant PcG accessory proteins, and discuss newly revealed roles of known PcG partners. We also examine the mechanisms by which the repression is achieved and how these complexes are recruited to target genes. Finally, we consider the possible role of some plant PcG proteins in mediating local and long-range chromatin interactions and, thus, shaping chromatin 3D architecture. The current picture of how the Polycomb Group repressive system acts at multiple levels to regulate gene expression in plants is examined and discussed in this review.
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DOI：
10.1093/plcell/koab139
发表时间：
2021-08-31
期刊：
The Plant cell
影响因子：
--
作者：
Baile F;Merini W;Hidalgo I;Calonje M
通讯作者：
Calonje M
影响因子：
4.6
作者：
Chanvivattana, Y;Bishopp, A;Goodrich, J
通讯作者：
Goodrich, J
影响因子：
27.5
作者：
Bratzel, Fabian;Yang, Chao;Calonje, Myriam
通讯作者：
Calonje, Myriam
DOI：
10.1073/pnas.1118678109
发表时间：
2012-05-01
影响因子：
11.1
作者：
Beh, Leslie Y.;Colwell, Lucy J.;Francis, Nicole J.
通讯作者：
Francis, Nicole J.
DOI：
10.1038/nrm4067
发表时间：
2015-11
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Blackledge NP;Rose NR;Klose RJ
通讯作者：
Klose RJ