Frictional characteristics of erythrocytes on coated glass plates subject to inclined centrifugal forces.
Frictional characteristics of erythrocytes on coated glass plates subject to inclined centrifugal forces.
复制标题
红细胞在涂层玻璃板上受到倾斜离心力的摩擦特性。
DOI：
10.1115/1.2948420
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
A. Shirai
中科院分区：
文献类型：
--
作者：
Takashi Kandori;T. Hayase;Kousuke Inoue;Kenichi Funamoto;T. Takeno;M. Ohta;M. Takeda;A. Shirai
近年来，类金刚石碳（DLC）膜和2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）聚合物作为用于可植入人工器官或装置的涂层材料引起了关注。当这些材料涂覆在血管装置上时，与血液的相容性是一个重要的问题。本文着重研究了红细胞在介质中对这些涂层材料的摩擦特性。用自行研制的倾斜离心显微镜，观察了红细胞在倾斜离心力作用下，在血浆或生理盐水介质中，在有涂层和无涂层平板玻璃上的运动。然后测量红细胞相对于这些涂层材料的摩擦特性，并相互比较，以表征DLC和MPC作为涂层材料。使用DLC涂覆和未涂覆的玻璃板的血浆中的红细胞的摩擦特性是相似的，与细胞速度的0.5次方近似成比例地变化。在盐水中，细胞也粘附在这些板上，这意味着血浆蛋白的影响。在等离子体中使用MPC涂覆的板的结果对于大的细胞速度与其他板的结果相似，但是随着细胞速度的降低而偏离其他结果。在小速度范围内，结果几乎与细胞速度的0.75次方成正比。盐水中MPC涂层板的结果与血浆中的结果相似，但略小，这意味着MPC涂层板的摩擦特性基本上与血浆蛋白无关。
In recent years a diamond-like carbon (DLC) film and a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer have attracted attention as coating materials for implantable artificial organs or devices. When these materials are coated on vascular devices, compatibility to blood is an important problem. The present paper focuses on friction characteristics of erythrocytes to these coating materials in a medium. With an inclined centrifuge microscope developed by the authors, observation was made for erythrocytes moving on flat glass plates with and without coating in a medium of plasma or saline under the effect of inclined centrifugal force. Friction characteristics of erythrocytes with respect to these coating materials were then measured and compared to each other to characterize DLC and MPC as coating materials. The friction characteristics of erythrocytes in plasma using the DLC-coated and noncoated glass plates are similar, changing approximately proportional to the 0.5th power of the cell velocity. The cells stick to these plates in saline as well, implying the influence of plasma protein. The results using the MPC-coated plate in plasma are similar to those of the other plates for large cell velocities, but deviate from the other results with decreased cell velocity. The results change nearly proportional to the 0.75th power of the cell velocity in the range of small velocities. The results for the MPC-coated plate in saline are similar to that in plasma but somewhat smaller, implying that the friction characteristics for the MPC-coated plate are essentially independent of plasma protein.
DOI：
10.1152/ajpheart.1998.274.3.h1016
发表时间：
1998-03-01
影响因子：
4.8
作者：
Secomb, TW;Hsu, R;Pries, AR
通讯作者：
Pries, AR