Trends in the Incidence of Fatal Prostate Cancer in the United States by Race.
Trends in the Incidence of Fatal Prostate Cancer in the United States by Race.
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DOI：
10.1016/j.eururo.2016.05.011
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发表时间：
2017-03
期刊：
影响因子：
23.4
通讯作者：
Cook MB
中科院分区：
文献类型：
--
作者：
Kelly SP;Rosenberg PS;Anderson WF;Andreotti G;Younes N;Cleary SD;Cook MB
前列腺特异性抗原（PSA）检测极大地改变了前列腺癌的组成，使其难以解释发病率趋势。需要新的方法来检查“临床显著”前列腺癌发病率的时间趋势，以及趋势是否因种族而异。对“临床显著”前列腺癌的发病率趋势进行深入分析，定义为前列腺癌是诊断后10年内死亡的根本原因的病例。我们从基于人群的监测、流行病学和最终结果项目数据库中的9个癌症登记处提取了1975-2002年期间的前列腺癌病例，以及截至2012年的相关死亡和生存原因。我们应用联合点回归分析来确定何时发生趋势的显著变化，并应用年龄-时期-队列模型来检查致命性前列腺癌发病率的纵向和横截面趋势。在51，680例致死性前列腺癌病例中，发病率在1992年之前每年增加1%，从1992-1995年每年下降15%，到2002年每年进一步下降5%。在≥60岁的男性中，致死性疾病的特异性发病率每年下降2%以上，而在≤55岁的男性中，发病率保持相对稳定。与白色男性相比，黑人男性的致死性疾病率高出2倍以上，在年轻男性中，种族差异增加到4.2倍。在广泛的PSA筛查和治疗进展后，致命性前列腺癌的发病率大幅下降。然而，年轻男性的致命疾病率保持相对稳定，这表明需要对早发性前列腺癌给予额外关注，特别是在黑人男性中。在致死性前列腺癌中观察到的持续的黑人与白色种族差异强调了需要更好地了解这种差异的原因，以便实施消除种族差异的策略。
Prostate-specific antigen (PSA) testing has dramatically changed the composition of prostate cancer, making it difficult to interpret incidence trends. New methods are needed to examine temporal trends in the incidence of “clinically significant” prostate cancer, and whether trends vary by race. To conduct an in-depth analysis of incidence trends in “clinically significant” prostate cancer, defined as cases in which prostate cancer was the underlying cause of death within 10-years of diagnosis. We extracted incident prostate cancer cases during 1975–2002, as well as associated causes of death and survival through 2012, from 9 cancer registries in the population-based Surveillance, Epidemiology, and End Results program database. We applied joinpoint regression analysis to identify when significant changes in trends occurred and age-period-cohort models to examine longitudinal and cross-sectional trends in the incidence of fatal prostate cancer. Among 51,680 fatal prostate cancer cases, incidence increased 1% per year prior to 1992, declined 15% per year from 1992–1995, and further declined by 5% per year through 2002. Age-specific incidence rates of fatal disease decreased over 2% per year among men ≥60 years, yet rates remained relatively stable among men ≤55 years. Fatal disease rates were more than 2-fold higher in black men compared with white men, a racial disparity that increased to 4.2 fold among younger men. The incidence of fatal prostate cancer has substantially declined after widespread PSA screening and treatment advances. Yet, rates of fatal disease among younger men have remained relatively stable, suggesting the need for additional attention on early-onset prostate cancer, especially among black men. The persistent black-to-white racial disparity observed in fatal prostate cancer underscores the need for a greater understanding of the causes for this difference so that strategies may be implemented to eliminate racial disparities.
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1975年至2012年，向国家报告癌症状况的年度报告，其发病率不断增加。
影响因子：
6.2
作者：
Ryerson AB;Eheman CR;Altekruse SF;Ward JW;Jemal A;Sherman RL;Henley SJ;Holtzman D;Lake A;Noone AM;Anderson RN;Ma J;Ly KN;Cronin KA;Penberthy L;Kohler BA
通讯作者：
Kohler BA
影响因子：
10.3
作者：
Han, Ying;Rand, Kristin A.;Haiman, Christopher A.
通讯作者：
Haiman, Christopher A.
影响因子：
10.3
作者：
Epstein, Mara M.;Edgren, Gustaf;Adami, Hans-Olov
通讯作者：
Adami, Hans-Olov
影响因子：
2.8
作者：
Cook, Michael B.;Rosenberg, Philip S.;Anderson, William F.
通讯作者：
Anderson, William F.
影响因子：
6.2
作者：
Cooperberg, Matthew R.;Vickers, Andrew J.;Broering, Jeanette M.;Carroll, Peter R.
通讯作者：
Carroll, Peter R.