Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?
Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?
复制标题
短链脂肪酸及其产生菌：炎症性肠病的一种被忽视的疗法？
DOI：
10.1016/j.ebiom.2021.103293
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发表时间：
2021-04
期刊：
影响因子：
11.1
通讯作者：
Vermeire S
中科院分区：
文献类型：
--
作者：
Deleu S;Machiels K;Raes J;Verbeke K;Vermeire S
肠道微生物组和肠道免疫系统是炎症性肠病（IBD）的驱动因素。两者都有一个共同的重要信号因子：短链脂肪酸（SCFAs）。SCFAs（乙酸、丙酸和丁酸）由肠道中的细菌发酵产生，对宿主代谢和免疫系统产生多种影响。本文综述了目前对这些影响的认识，特别关注IBD的能量代谢，肠道屏障，免疫系统和疾病活动。总之，需要对肠道微生物组中的交叉摄食机制以及SCFA对不同疾病模型的治疗潜力进行更多的研究。此外，随机对照试验和前瞻性队列研究应调查SCFA给药的临床影响。
The gut microbiome and the intestinal immune system are driving contributors to inflammatory bowel diseases (IBD). Both have an important signalling factor in common: short-chain fatty acids (SCFAs). SCFAs (acetate, propionate and butyrate) are produced by bacterial fermentation in the gut and exert several effects on host metabolism and immune system. This review provides an overview of the current knowledge of these effects, with specific focus on energy metabolism, intestinal barrier, immune system, and disease activity in IBD. To conclude, more research is needed on the cross-feeding mechanisms in the gut microbiome, as well as on the therapeutic potential of SCFAs on different disease models. Also randomized controlled trials and prospective cohort studies should investigate the clinical impact of SCFA administration.
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