Single Application Cold-Chain Independent Drug Delivery System for Outer Ear Infections.
Single Application Cold-Chain Independent Drug Delivery System for Outer Ear Infections.
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DOI：
10.1021/acsbiomaterials.0c01223
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发表时间：
2020-10-12
影响因子：
5.8
通讯作者：
Serban MA
中科院分区：
文献类型：
--
作者：
Serban BA;Shi K;Alverson JB;Hoody J;Priestley ND;Park AH;Serban MA
外耳感染（OE）每年影响数百万人，并产生重大的相关医疗费用。不正确的给药或不依从治疗方案可导致感染持续、复发、抗生素耐药性，严重时可加重恶性外耳炎。这些问题对于军事人员、疗养院的病人、老年人、头部或手部震颤的病人以及那些获得适当医疗保健的机会有限或无法获得适当医疗保健的人来说尤其重要。为了使用传统的材料科学原理去卷积材料设计，同时增加相关性和有效性，我们开发了一种单一应用，冷链独立触变药物递送系统。这可以很容易地应用到耳朵作为一种液体，然后凝胶提供有效浓度的抗生素对细菌菌株通常与OE。该系统保持触变性能在几个应力/无应力周期，显示可忽略的肿胀和温度依赖性，并不影响最低抑菌浓度或相关抗生素的杀菌效果。此外，触变凝胶是生物相容的，并且在耳中耐受良好。这种药物递送系统可以容易地转化为用户友好的产品，可以通过诊断医疗保健提供者的单次应用来提高依从性，预计可以有效地治疗OE并最大限度地减少抗生素耐药性的发展、感染复发或恶化。我们介绍一种一次性使用的药物输送系统，安全有效地治疗外耳炎。
Outer ear infections (OE) affect millions of people annually with significant associated healthcare costs. Incorrect administration or non-compliance with the treatment regimen can lead to infection persistence, recurrence, antibiotic resistance, and in severe cases aggravation to malignant otitis externa. Such issues are particularly pertinent for military personnel, patients in nursing homes, the geriatric population, for patients with head or hand tremors and for those with limited or no access to proper healthcare. With the intent of using traditional material science principles to deconvolute material design while increasing relevance and efficacy, we developed a single application, cold-chain independent thixotropic drug delivery system. This can be easily applied into the ear as a liquid, then gels to deliver effective concentrations of antibiotics against bacterial strains commonly associated with OE. The system maintains thixotropic properties over several stress/no stress cycles, shows negligible swelling and temperature dependence, and does not impact the minimum inhibitory concentration or bactericidal effects of relevant antibiotics. Moreover, the thixogels are biocompatible and are well tolerated in the ear. This drug delivery system can readily translate into a user-friendly product, could improve compliance via a single application by the diagnosing health care provider, is expected to effectively treat OE and minimize the development of antibiotic resistance, infection recurrence or exacerbation. We introduce a single use drug delivery system to safely and effectively treat otitis externa.
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DOI：
10.1111/nyas.12886
发表时间：
2015-01-01
期刊：
PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: PRIX GALIEN 2014
影响因子：
--
作者：
Jewell, Mark;Daunch, William;Mortarino, Enrico
通讯作者：
Mortarino, Enrico
影响因子：
2.6
作者：
Berenholz, L;Katzenell, U;Harell, M
通讯作者：
Harell, M
影响因子：
1.9
作者：
Lee, Hobart;Kim, Jeffrey;Van Nguyen
通讯作者：
Van Nguyen
影响因子：
1.3
作者：
Bhasker, Diana;Hartley, Angela;Agada, Frank
通讯作者：
Agada, Frank
影响因子：
1.7
作者：
Chawdhary, G.;Liow, N.;Whiteside, O.
通讯作者：
Whiteside, O.