Immunological mechanisms of vaccination.

Immunological mechanisms of vaccination.
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疫苗接种的免疫机制。

DOI:
10.1038/ni.2039
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发表时间:
2011-06
期刊:
影响因子:
30.5
通讯作者:
Ahmed R
Ahmed R
中科院分区:
医学1区
文献类型:
--
作者:
Pulendran B;Ahmed R

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疫苗是现代医学最伟大的成就之一。尽管疫苗学和免疫学在200多年前有共同的起源,但这两个学科沿着不同的轨迹发展,以至于大多数非常成功的疫苗都是根据经验制造的,很少或根本没有免疫学知识。先天免疫的最新进展为疫苗诱导免疫的机制提供了新的见解,并促进了更合理的疫苗设计方法。在这里,我们将讨论这些进展和新主题的免疫接种。
Vaccines represent one of the greatest triumphs of modern medicine. Despite the common origins of vaccinology and immunology more than 200 years ago, the two disciplines have evolved along such different trajectories that most of the highly successful vaccines have been made empirically, with little or no immunological insight. Recent advances in innate immunity have offered new insights about the mechanisms of vaccine-induced immunity and have facilitated a more rational approach to vaccine design. Here we will discuss these advances and emerging themes on the immunology of vaccination.
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影响因子: 16.8
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